Seroatlas · Human Serome Atlas

CBLN1

Cerebellin-1

Also known as: CBLN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P23435
Gene
CBLN1
Ensembl
ENSG00000102924
Chromosome
16
Canonical length
193 aa
Protein class
Predicted secreted proteins
Subcellular location
Cytosol,Perinuclear theca,Calyx,Flagellar centriole,Mid piece,Principal piece
Secretome location
Secreted in brain
Quaternary structure
Homohexamer

OverviewNCBI Gene

This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>P23435|CBLN1
     1  MLGVLELLLL GAAWLAGPAR GQNETEPIVL EGKCLVVCDS NPTSDPTGTA LGISVRSGSA
    61  KVAFSAIRST NHEPSEMSNR TMIIYFDQVL VNIGNNFDSE RSTFIAPRKG IYSFNFHVVK
   121  VYNRQTIQVS LMLNGWPVIS AFAGDQDVTR EAASNGVLIQ MEKGDRAYLK LERGNLMGGW
   181  KYSTFSGFLV FPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CBLN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
425 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 425 nTPM
  • hypothalamus: 34 nTPM
  • testis: 30 nTPM
  • midbrain: 17 nTPM
  • adipose tissue: 11 nTPM
  • spinal cord: 9.1 nTPM

Single-cell type

  • late spermatids: 523 nCPM
  • late primary spermatocytes: 153 nCPM
  • early spermatids: 86 nCPM
  • brain excitatory neurons: 64 nCPM
  • vascular smooth muscle cells: 18 nCPM
  • early primary spermatocytes: 13 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 239 nTPM
  • hypothalamus: 54 nTPM
  • midbrain: 37 nTPM
  • pons: 27 nTPM
  • thalamus: 26 nTPM
  • medulla oblongata: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0.18
gnomAD missense Z
1.68
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CBLN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CBLN1 as an antibody target. Whether an autoantibody or antibody against CBLN1 could matter depends on whether native CBLN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CBLN1 is annotated at the cell surface, where native CBLN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CBLN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CBLN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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