Seroatlas · Human Serome Atlas

MLANA

Melanoma antigen recognized by T-cells 1

Also known as: MAR1_HUMAN, MART-1, MART1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16655
Gene
MLANA
Ensembl
ENSG00000120215
Chromosome
9
Canonical length
118 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Located in endoplasmic reticulum membrane; melanosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>Q16655|MLANA
     1  MPREDAHFIY GYPKKGHGHS YTTAEEAAGI GILTVILGVL LLIGCWYCRR RNGYRALMDK
    61  SLHVGTQCAL TRRCPQEGFD HRDSKVSLQE KNCEPVVPNA PPAYEKLSAE QSPPPYSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MLANA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • skin: 41 nTPM
  • breast: 1.3 nTPM
  • salivary gland: 0.9 nTPM
  • bone marrow: 0.6 nTPM
  • appendix: 0.4 nTPM
  • liver: 0.4 nTPM

Single-cell type

  • melanocytes: 2,724 nCPM
  • cardiomyocytes: 88 nCPM
  • epicardial cells: 82 nCPM
  • basal keratinocytes: 32 nCPM
  • adipocytes: 31 nCPM
  • retinal pigment epithelial cells: 26 nCPM

Immune cell

  • basophil: 0.6 nTPM
  • neutrophil: 0.3 nTPM
  • naive B-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • choroid plexus: 17 nTPM
  • cerebellum: 8.3 nTPM
  • cerebral cortex: 6.1 nTPM
  • white matter: 5.9 nTPM
  • thalamus: 5.7 nTPM
  • pons: 5.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MLANA.

Disease | ImmuneIEDB

Conditions an epitope on MLANA was assayed in.

ReferencesPubMed · IEDB

Publications for MLANA from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

2 publications

Reference: B cellIEDB

3 publications

Reference: T cellIEDB

91 publications

Show 20 more of 91 total

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.95
gnomAD pLI
0
gnomAD missense Z
-0.12
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein melan-A
  • Protein melan-A

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MLANA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MLANA as an antibody target. Whether an autoantibody or antibody against MLANA could matter depends on whether native MLANA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MLANA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MLANA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MLANA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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