Seroatlas · Human Serome Atlas

GPBP1

Vasculin

Also known as: DKFZp761C169, GPBP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WP2
Gene: GPBP1
Ensembl: ENSG00000062194
Chromosome: 5
Canonical length: 473 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

473 residues, UniProt reviewed canonical sequence.

>Q86WP2|GPBP1
     1  MAQHDFAPAW LNFPTPPSST KSSLNFEKHS ENFAWTENRY DVNRRRHNSS DGFDSAIGRP
    61  NGGNFGRKEK NGWRTHGRNG TENINHRGGY HGGSSRSRSS IFHAGKSQGL HENNIPDNET
   121  GRKEDKRERK QFEAEDFPSL NPEYEREPNH NKSLAAGVWE YPPNPKSRAP RMLVIKKGNT
   181  KDLQLSGFPV VGNLPSQPVK NGTGPSVYKG LVPKPAAPPT KPTQWKSQTK ENKVGTSFPH
   241  ESTFGVGNFN AFKSTAKNFS PSTNSVKECN RSNSSSPVDK LNQQPRLTKL TRMRTDKKSE
   301  FLKALKRDRV EEEHEDESRA GSEKDDDSFN LHNSNSTHQE RDINRNFDEN EIPQENGNAS
   361  VISQQIIRSS TFPQTDVLSS SLEAEHRLLK EMGWQEDSEN DETCAPLTED EMREFQVISE
   421  QLQKNGLRKN GILKNGLICD FKFGPWKNST FKPTTENDDT ETSSSDTSDD DDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

retina: 78 nTPM
cerebellum: 73 nTPM
testis: 70 nTPM
thymus: 64 nTPM
bone marrow: 62 nTPM
ovary: 58 nTPM

Single-cell type

neutrophils: 956 nCPM
endometrial glandular cells: 557 nCPM
cdc: 550 nCPM
endometrial ciliated cells: 500 nCPM
early primary spermatocytes: 469 nCPM
endometrial luminal cells: 451 nCPM

Immune cell

basophil: 94 nTPM
T-reg: 85 nTPM
NK-cell: 80 nTPM
naive CD4 T-cell: 79 nTPM
eosinophil: 77 nTPM
MAIT T-cell: 76 nTPM

Brain region

cerebellum: 100 nTPM
white matter: 93 nTPM
cerebral cortex: 67 nTPM
basal ganglia: 66 nTPM
spinal cord: 61 nTPM
midbrain: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.42
gnomAD missense Z: 1.17
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPBP1 as an antibody target. Whether an autoantibody or antibody against GPBP1 could matter depends on whether native GPBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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