Seroatlas · Human Serome Atlas

GLOD4

Glyoxalase domain-containing protein 4

Also known as: C17orf25, CGI-150, GLOD4_HUMAN, HC71

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HC38
Gene: GLOD4
Ensembl: ENSG00000167699
Chromosome: 17
Canonical length: 313 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables cadherin binding activity. Located in extracellular exosome and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q9HC38|GLOD4
     1  MAARRALHFV FKVGNRFQTA RFYRDVLGMK VESCSVARLE CSGAISAHCS DYTRITEDSF
    61  SKPYDGKWSK TMVGFGPEDD HFVAELTYNY GVGDYKLGND FMGITLASSQ AVSNARKLEW
   121  PLTEVAEGVF ETEAPGGYKF YLQNRSLPQS DPVLKVTLAV SDLQKSLNYW CNLLGMKIYE
   181  KDEEKQRALL GYADNQCKLE LQGVKGGVDH AAAFGRIAFS CPQKELPDLE DLMKRENQKI
   241  LTPLVSLDTP GKATVQVVIL ADPDGHEICF VGDEAFRELS KMDPEGSKLL DDAMAADKSD
   301  EWFAKHNKPK ASG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLOD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 82 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 82 nTPM
stomach: 72 nTPM
kidney: 69 nTPM
liver: 68 nTPM
duodenum: 65 nTPM
colon: 64 nTPM

Single-cell type

parietal cells: 810 nCPM
migrating cytotrophoblasts: 129 nCPM
cytotrophoblasts: 119 nCPM
hofbauer cells: 109 nCPM
enterocytes: 102 nCPM
extravillous trophoblasts: 99 nCPM

Immune cell

T-reg: 84 nTPM
memory CD4 T-cell: 70 nTPM
memory CD8 T-cell: 68 nTPM
total PBMC: 67 nTPM
naive B-cell: 63 nTPM
MAIT T-cell: 62 nTPM

Brain region

choroid plexus: 38 nTPM
hypothalamus: 36 nTPM
basal ganglia: 25 nTPM
cerebral cortex: 24 nTPM
pons: 22 nTPM
spinal cord: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: 0.01
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

cadherin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Vicinal oxygen chelate (VOC), core domain
Glyoxalase domain-containing protein 4
Glyoxalase domain-containing protein 4, C-terminal
Glyoxalase domain-containing protein 4 domain
Glyoxalase domain-containing protein 4, N-terminal
Glyoxalasedomain-containing protein 4-like, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GLOD4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NUDT9

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLOD4 as an antibody target. Whether an autoantibody or antibody against GLOD4 could matter depends on whether native GLOD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLOD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GLOD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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