Seroatlas · Human Serome Atlas

NUDT9

ADP-ribose pyrophosphatase, mitochondrial

Also known as: MGC3037, NUDT9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BW91
Gene
NUDT9
Ensembl
ENSG00000170502
Chromosome
4
Canonical length
350 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nuclear membrane,Nuclear bodies,Cell Junctions,Mitochondria
Secretome location
Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q9BW91|NUDT9
     1  MAGRLLGKAL AAVSLSLALA SVTIRSSRCR GIQAFRNSFS SSWFHLNTNV MSGSNGSKEN
    61  SHNKARTSPY PGSKVERSQV PNEKVGWLVE WQDYKPVEYT AVSVLAGPRW ADPQISESNF
   121  SPKFNEKDGH VERKSKNGLY EIENGRPRNP AGRTGLVGRG LLGRWGPNHA ADPIITRWKR
   181  DSSGNKIMHP VSGKHILQFV AIKRKDCGEW AIPGGMVDPG EKISATLKRE FGEEALNSLQ
   241  KTSAEKREIE EKLHKLFSQD HLVIYKGYVD DPRNTDNAWM ETEAVNYHDE TGEIMDNLML
   301  EAGDDAGKVK WVDINDKLKL YASHSQFIKL VAEKRDAHWS EDSEADCHAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
91 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 91 nTPM
  • pancreas: 64 nTPM
  • parathyroid gland: 52 nTPM
  • liver: 44 nTPM
  • tongue: 42 nTPM
  • duodenum: 40 nTPM

Single-cell type

  • pancreatic islet cells: 84 nCPM
  • alveolar cells type 1: 78 nCPM
  • cone photoreceptor cells: 73 nCPM
  • transitional alveolar cells: 71 nCPM
  • prostatic glandular cells: 71 nCPM
  • pancreatic acinar cells: 70 nCPM

Immune cell

  • naive CD8 T-cell: 26 nTPM
  • non-classical monocyte: 24 nTPM
  • naive CD4 T-cell: 23 nTPM
  • memory B-cell: 22 nTPM
  • myeloid DC: 21 nTPM
  • intermediate monocyte: 21 nTPM

Brain region

  • choroid plexus: 69 nTPM
  • white matter: 33 nTPM
  • cerebellum: 30 nTPM
  • hypothalamus: 29 nTPM
  • cerebral cortex: 28 nTPM
  • basal ganglia: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
1.03
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUDT9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDT9 as an antibody target. Whether an autoantibody or antibody against NUDT9 could matter depends on whether native NUDT9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDT9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDT9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUDT9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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