Seroatlas · Human Serome Atlas

GINS4

DNA replication complex GINS protein SLD5

Also known as: MGC14799, SLD5, SLD5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BRT9
Gene
GINS4
Ensembl
ENSG00000147536
Chromosome
8
Canonical length
223 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome

OverviewNCBI Gene

The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>Q9BRT9|GINS4
     1  MTEEVDFLGQ DSDGGSEEVV LTPAELIERL EQAWMNEKFA PELLESKPEI VECVMEQLEH
    61  MEENLRRAKR EDLKVSIHQM EMERIRYVLS SYLRCRLMKI EKFFPHVLEK EKTRPEGEPS
   121  SLSPEELAFA REFMANTESY LKNVALKHMP PNLQKVDLFR AVPKPDLDSY VFLRVRERQE
   181  NILVEPDTDE QRDYVIDLEK GSQHLIRYKT IAPLVASGAV QLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GINS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
5.7 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 5.7 nTPM
  • tonsil: 5.6 nTPM
  • bone marrow: 5.4 nTPM
  • lymph node: 4.7 nTPM
  • appendix: 3.7 nTPM
  • rectum: 2.8 nTPM

Single-cell type

  • neutrophils: 36 nCPM
  • megakaryocyte progenitors: 28 nCPM
  • monocyte progenitors: 26 nCPM
  • erythrocyte progenitors: 26 nCPM
  • extravillous trophoblasts: 16 nCPM
  • differentiating spermatogonia: 14 nCPM

Immune cell

  • T-reg: 3.6 nTPM
  • naive B-cell: 2.8 nTPM
  • plasmacytoid DC: 2.8 nTPM
  • memory CD4 T-cell: 2.5 nTPM
  • neutrophil: 1.6 nTPM
  • gdT-cell: 1.5 nTPM

Brain region

  • white matter: 7 nTPM
  • medulla oblongata: 5.5 nTPM
  • cerebellum: 5.4 nTPM
  • cerebral cortex: 5 nTPM
  • basal ganglia: 4.9 nTPM
  • pons: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
0.54
DepMap mean gene effect
-1.39
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GINS4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GINS4 as an antibody target. Whether an autoantibody or antibody against GINS4 could matter depends on whether native GINS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GINS4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GINS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GINS4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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