Seroatlas · Human Serome Atlas

SIK1

Serine/threonine-protein kinase SIK1

Also known as: msk, SIK1_HUMAN, SNF1LK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P57059
Gene
SIK1
Ensembl
ENSG00000142178
Chromosome
21
Canonical length
783 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30. [provided by RefSeq, Nov 2016]

Canonical amino-acid sequenceUniProt

783 residues, UniProt reviewed canonical sequence.

>P57059|SIK1
     1  MVIMSEFSAD PAGQGQGQQK PLRVGFYDIE RTLGKGNFAV VKLARHRVTK TQVAIKIIDK
    61  TRLDSSNLEK IYREVQLMKL LNHPHIIKLY QVMETKDMLY IVTEFAKNGE MFDYLTSNGH
   121  LSENEARKKF WQILSAVEYC HDHHIVHRDL KTENLLLDGN MDIKLADFGF GNFYKSGEPL
   181  STWCGSPPYA APEVFEGKEY EGPQLDIWSL GVVLYVLVCG SLPFDGPNLP TLRQRVLEGR
   241  FRIPFFMSQD CESLIRRMLV VDPARRITIA QIRQHRWMRA EPCLPGPACP AFSAHSYTSN
   301  LGDYDEQALG IMQTLGVDRQ RTVESLQNSS YNHFAAIYYL LLERLKEYRN AQCARPGPAR
   361  QPRPRSSDLS GLEVPQEGLS TDPFRPALLC PQPQTLVQSV LQAEMDCELQ SSLQWPLFFP
   421  VDASCSGVFR PRPVSPSSLL DTAISEEARQ GPGLEEEQDT QESLPSSTGR RHTLAEVSTR
   481  LSPLTAPCIV VSPSTTASPA EGTSSDSCLT FSASKSPAGL SGTPATQGLL GACSPVRLAS
   541  PFLGSQSATP VLQAQGGLGG AVLLPVSFQE GRRASDTSLT QGLKAFRQQL RKTTRTKGFL
   601  GLNKIKGLAR QVCQAPASRA SRGGLSPFHA PAQSPGLHGG AAGSREGWSL LEEVLEQQRL
   661  LQLQHHPAAA PGCSQAPQPA PAPFVIAPCD GPGAAPLPST LLTSGLPLLP PPLLQTGASP
   721  VASAAQLLDT HLHIGTGPTA LPAVPPPRLA RLAPGCEPLG LLQGDCEMED LMPCSLGTFV
   781  LVQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
82 nTPM

Expression across tissuesHPA

Tissue

  • skin: 82 nTPM
  • urinary bladder: 57 nTPM
  • pancreas: 55 nTPM
  • seminal vesicle: 52 nTPM
  • adrenal gland: 51 nTPM
  • bone marrow: 50 nTPM

Single-cell type

  • suprabasal keratinocytes: 29 nCPM
  • basal keratinocytes: 15 nCPM
  • endometrial glandular cells: 10 nCPM
  • papillary tip epithelial cells: 8.2 nCPM
  • medullary thymic epithelial cells: 7.2 nCPM
  • endometrial luminal cells: 5.9 nCPM

Immune cell

  • plasmacytoid DC: 2 nTPM
  • memory B-cell: 0.9 nTPM
  • naive B-cell: 0.6 nTPM
  • non-classical monocyte: 0.6 nTPM
  • intermediate monocyte: 0.3 nTPM
  • myeloid DC: 0.3 nTPM

Brain region

  • cerebral cortex: 33 nTPM
  • hypothalamus: 30 nTPM
  • medulla oblongata: 29 nTPM
  • pons: 22 nTPM
  • midbrain: 22 nTPM
  • thalamus: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SIK1.

Disease | AllUniProt

Conditions SIK1 is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 30 (DEE30) MIM:616341

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 1,106 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.94
gnomAD missense Z
1.49
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIK1 as an antibody target. Whether an autoantibody or antibody against SIK1 could matter depends on whether native SIK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SIK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SIK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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