Seroatlas · Human Serome Atlas

GINS2

DNA replication complex GINS protein PSF2

Also known as: Pfs2, PSF2, PSF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y248
Gene: GINS2
Ensembl: ENSG00000131153
Chromosome: 16
Canonical length: 185 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

185 residues, UniProt reviewed canonical sequence.

>Q9Y248|GINS2
     1  MDAAEVEFLA EKELVTIIPN FSLDKIYLIG GDLGPFNPGL PVEVPLWLAI NLKQRQKCRL
    61  LPPEWMDVEK LEKMRDHERK EETFTPMPSP YYMELTKLLL NHASDNIPKA DEIRTLVKDM
   121  WDTRIAKLRV SADSFVRQQE AHAKLDNLTL MEINTSGTFL TQALNHMYKL RTNLQPLEST
   181  QSQDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GINS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 14 nTPM
retina: 10 nTPM
tonsil: 10 nTPM
thymus: 9.5 nTPM
testis: 9 nTPM
lymph node: 8.4 nTPM

Single-cell type

oocytes: 424 nCPM
early primary spermatocytes: 247 nCPM
differentiating spermatogonia: 118 nCPM
erythrocyte progenitors: 73 nCPM
syncytiotrophoblasts: 72 nCPM
esophageal basal cells: 66 nCPM

Immune cell

T-reg: 8.5 nTPM
memory CD4 T-cell: 3.3 nTPM
NK-cell: 3.2 nTPM
non-classical monocyte: 2.9 nTPM
memory CD8 T-cell: 2.3 nTPM
total PBMC: 1.7 nTPM

Brain region

hippocampal formation: 7.5 nTPM
cerebral cortex: 5.7 nTPM
amygdala: 4.3 nTPM
cerebellum: 4.2 nTPM
basal ganglia: 3.9 nTPM
white matter: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
gnomAD missense Z: -1.32
DepMap mean gene effect: -2.07
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

GINS subunit, domain A
GINS, helical bundle-like domain superfamily
GINS complex protein helical bundle domain
DNA replication complex GINS protein Psf2
DNA replication complex GINS protein PSF2, N-terminal domain
PSF2 N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GINS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GINS2 as an antibody target. Whether an autoantibody or antibody against GINS2 could matter depends on whether native GINS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GINS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GINS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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