Seroatlas · Human Serome Atlas

GINS3

DNA replication complex GINS protein PSF3

Also known as: FLJ13912, PSF3, PSF3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BRX5
Gene
GINS3
Ensembl
ENSG00000181938
Chromosome
16
Canonical length
216 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>Q9BRX5|GINS3
     1  MSEAYFRVES GALGPEENFL SLDDILMSHE KLPVRTETAM PRLGAFFLER SAGAETDNAV
    61  PQGSKLELPL WLAKGLFDNK RRILSVELPK IYQEGWRTVF SADPNVVDLH KMGPHFYGFG
   121  SQLLHFDSPE NADISQSLLQ TFIGRFRRIM DSSQNAYNED TSALVARLDE MERGLFQTGQ
   181  KGLNDFQCWE KGQASQITAS NLVQNYKKRK FTDMED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GINS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
8.9 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 8.9 nTPM
  • basal ganglia: 8.3 nTPM
  • thymus: 8.2 nTPM
  • bone marrow: 7.9 nTPM
  • tonsil: 7.5 nTPM
  • lymph node: 7.3 nTPM

Single-cell type

  • astrocytes: 233 nCPM
  • early spermatids: 118 nCPM
  • late primary spermatocytes: 100 nCPM
  • schwann cells: 85 nCPM
  • oligodendrocyte progenitor cells: 76 nCPM
  • ependymal cells: 69 nCPM

Immune cell

  • plasmacytoid DC: 8.2 nTPM
  • naive B-cell: 4.4 nTPM
  • myeloid DC: 4.1 nTPM
  • NK-cell: 4.1 nTPM
  • memory CD8 T-cell: 2.9 nTPM
  • memory B-cell: 2.5 nTPM

Brain region

  • basal ganglia: 7.8 nTPM
  • cerebellum: 6.7 nTPM
  • midbrain: 6.5 nTPM
  • thalamus: 5.8 nTPM
  • medulla oblongata: 5.3 nTPM
  • spinal cord: 4.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GINS3.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Meier-Gorlin syndrome 9

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.52
gnomAD pLI
0
gnomAD missense Z
0.46
DepMap mean gene effect
-1.13
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GINS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GINS3 as an antibody target. Whether an autoantibody or antibody against GINS3 could matter depends on whether native GINS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GINS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GINS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GINS3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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