Seroatlas · Human Serome Atlas

GGNBP1

Putative gametogenetin-binding protein 1

Also known as: GGNB1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5YKI7
Gene: GGNBP1
Canonical length: 109 aa

OverviewNCBI Gene

No narrative summary is available for GGNBP1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

109 residues, UniProt reviewed canonical sequence.

>Q5YKI7|GGNBP1
     1  MKEEDSSFKL CVPGIVALQS PPNKAFRSTD TVGFLESELK KLLGMQQESR LWKLGSQEGR
    61  ELLTRPEITV VEGEGYEVQR RLRHLPSPIS VAQCLLLEEK GEMGNWPPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GGNBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.69
gnomAD missense Z: 1.35

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GGNBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GGNBP1 as an antibody target. Whether an autoantibody or antibody against GGNBP1 could matter depends on whether native GGNBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GGNBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GGNBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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