Seroatlas · Human Serome Atlas

GGNBP2

Gametogenetin-binding protein 2

Also known as: DIF-3, DIF3, FLJ21230, FLJ22561, GGNB2_HUMAN, LZK1, ZFP403, ZNF403

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H3C7
Gene: GGNBP2
Ensembl: ENSG00000278311
Chromosome: 17
Canonical length: 697 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Predicted to be involved in spermatogenesis. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of cell population proliferation; and negative regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

697 residues, UniProt reviewed canonical sequence.

>Q9H3C7|GGNBP2
     1  MARLVAVCRD GEEEFPFERR QIPLYIDDTL TMVMEFPDNV LNLDGHQNNG AQLKQFIQRH
    61  GMLKQQDLSI AMVVTSREVL SALSQLVPCV GCRRSVERLF SQLVESGNPA LEPLTVGPKG
   121  VLSVTRSCMT DAKKLYTLFY VHGSKLNDMI DAIPKSKKNK RCQLHSLDTH KPKPLGGCWM
   181  DVWELMSQEC RDEVVLIDSS CLLETLETYL RKHRFCTDCK NKVLRAYNIL IGELDCSKEK
   241  GYCAALYEGL RCCPHERHIH VCCETDFIAH LLGRAEPEFA GGRRERHAKT IDIAQEEVLT
   301  CLGIHLYERL HRIWQKLRAE EQTWQMLFYL GVDALRKSFE MTVEKVQGIS RLEQLCEEFS
   361  EEERVRELKQ EKKRQKRKNR RKNKCVCDIP TPLQTADEKE VSQEKETDFI ENSSCKACGS
   421  TEDGNTCVEV IVTNENTSCT CPSSGNLLGS PKIKKGLSPH CNGSDCGYSS SMEGSETGSR
   481  EGSDVACTEG ICNHDEHGDD SCVHHCEDKE DDGDSCVECW ANSEENDTKG KNKKKKKKSK
   541  ILKCDEHIQK LGSCITDPGN RETSGNTMHT VFHRDKTKDT HPESCCSSEK GGQPLPWFEH
   601  RKNVPQFAEP TETLFGPDSG KGAKSLVELL DESECTSDEE IFISQDEIQS FMANNQSFYS
   661  NREQYRQHLK EKFNKYCRLN DHKRPICSGW LTTAGAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GGNBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 75 nTPM
testis: 57 nTPM
blood vessel: 51 nTPM
skeletal muscle: 51 nTPM
lymph node: 47 nTPM
tonsil: 44 nTPM

Single-cell type

late primary spermatocytes: 578 nCPM
early spermatids: 333 nCPM
late spermatids: 123 nCPM
proximal tubule cells: 120 nCPM
early primary spermatocytes: 96 nCPM
microglia: 93 nCPM

Immune cell

plasmacytoid DC: 84 nTPM
eosinophil: 68 nTPM
naive CD4 T-cell: 66 nTPM
naive CD8 T-cell: 62 nTPM
memory B-cell: 57 nTPM
T-reg: 50 nTPM

Brain region

cerebellum: 33 nTPM
midbrain: 32 nTPM
pons: 32 nTPM
hypothalamus: 32 nTPM
white matter: 32 nTPM
medulla oblongata: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.07
gnomAD pLI: 1
gnomAD missense Z: 3.26
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Gametogenetin-binding protein 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GGNBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GGNBP2 as an antibody target. Whether an autoantibody or antibody against GGNBP2 could matter depends on whether native GGNBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GGNBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GGNBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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