FRK

Protein identityUniProt · HPA

UniProt accession

P42685

Gene

FRK

Ensembl

ENSG00000111816

Chromosome

6

Canonical length

505 aa

Protein class

Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>P42685|FRK
     1  MSNICQRLWE YLEPYLPCLS TEADKSTVIE NPGALCSPQS QRHGHYFVAL FDYQARTAED
    61  LSFRAGDKLQ VLDTLHEGWW FARHLEKRRD GSSQQLQGYI PSNYVAEDRS LQAEPWFFGA
   121  IGRSDAEKQL LYSENKTGSF LIRESESQKG EFSLSVLDGA VVKHYRIKRL DEGGFFLTRR
   181  RIFSTLNEFV SHYTKTSDGL CVKLGKPCLK IQVPAPFDLS YKTVDQWEID RNSIQLLKRL
   241  GSGQFGEVWE GLWNNTTPVA VKTLKPGSMD PNDFLREAQI MKNLRHPKLI QLYAVCTLED
   301  PIYIITELMR HGSLQEYLQN DTGSKIHLTQ QVDMAAQVAS GMAYLESRNY IHRDLAARNV
   361  LVGEHNIYKV ADFGLARVFK VDNEDIYESR HEIKLPVKWT APEAIRSNKF SIKSDVWSFG
   421  ILLYEIITYG KMPYSGMTGA QVIQMLAQNY RLPQPSNCPQ QFYNIMLECW NAEPKERPTF
   481  ETLRWKLEDY FETDSSYSDA NNFIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FRK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

8.4 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.08

gnomAD pLI

0

gnomAD missense Z

0.69

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell differentiation
• cell surface receptor protein tyrosine kinase signaling pathway
• negative regulation of transcription by RNA polymerase II

Molecular functions

• ATP binding
• non-membrane spanning protein tyrosine kinase activity
• protein tyrosine kinase activity
• signaling receptor binding

Cellular components

• azurophil granule lumen
• cytoplasm
• cytosol
• extracellular exosome
• extracellular region
• nucleoplasm
• nucleus
• plasma membrane
• specific granule lumen

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• SH2 domain
• Serine-threonine/tyrosine-protein kinase, catalytic domain
• SH3 domain
• Tyrosine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• Tyrosine-protein kinase, catalytic domain
• SH3-like domain superfamily
• SH2 domain superfamily
• Non-receptor tyrosine kinases involved in cell signaling
• SH2 domain
• SH3 domain
• Protein tyrosine and serine/threonine kinase
• Tyrosine-protein kinase Frk, SH2 domain

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Kinase
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• SH2 domain
• SH3 domain
• Transferase
• Tumor suppressor
• Tyrosine-protein kinase

InteractionsUniProt · HPA

Protein binding partners of FRK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RB1
• EGFR
• PTEN