Seroatlas · Human Serome Atlas

FNTB

Protein farnesyltransferase subunit beta

Also known as: FNTB_HUMAN, FPTB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49356
Gene
FNTB
Ensembl
ENSG00000257365
Chromosome
14
Canonical length
437 aa
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Centrosome

OverviewNCBI Gene

This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>P49356|FNTB
     1  MASPSSFTYY CPPSSSPVWS EPLYSLRPEH ARERLQDDSV ETVTSIEQAK VEEKIQEVFS
    61  SYKFNHLVPR LVLQREKHFH YLKRGLRQLT DAYECLDASR PWLCYWILHS LELLDEPIPQ
   121  IVATDVCQFL ELCQSPEGGF GGGPGQYPHL APTYAAVNAL CIIGTEEAYD IINREKLLQY
   181  LYSLKQPDGS FLMHVGGEVD VRSAYCAASV ASLTNIITPD LFEGTAEWIA RCQNWEGGIG
   241  GVPGMEAHGG YTFCGLAALV ILKRERSLNL KSLLQWVTSR QMRFEGGFQG RCNKLVDGCY
   301  SFWQAGLLPL LHRALHAQGD PALSMSHWMF HQQALQEYIL MCCQCPAGGL LDKPGKSRDF
   361  YHTCYCLSGL SIAQHFGSGA MLHDVVLGVP ENALQPTHPV YNIGPDKVIQ ATTYFLQKPV
   421  PGFEELKDET SAEPATD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FNTB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
136 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 136 nTPM
  • midbrain: 34 nTPM
  • skeletal muscle: 22 nTPM
  • tongue: 19 nTPM
  • esophagus: 17 nTPM
  • skin: 17 nTPM

Single-cell type

  • platelets: 132 nCPM
  • oligodendrocytes: 112 nCPM
  • bergmann glia: 52 nCPM
  • astrocytes: 51 nCPM
  • esophageal apical cells: 50 nCPM
  • choroid plexus epithelial cells: 49 nCPM

Immune cell

  • basophil: 22 nTPM
  • classical monocyte: 13 nTPM
  • eosinophil: 12 nTPM
  • intermediate monocyte: 9.9 nTPM
  • MAIT T-cell: 9.5 nTPM
  • myeloid DC: 7.3 nTPM

Brain region

  • white matter: 128 nTPM
  • medulla oblongata: 100 nTPM
  • cerebellum: 67 nTPM
  • pons: 63 nTPM
  • spinal cord: 58 nTPM
  • midbrain: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.08
gnomAD missense Z
1.38
DepMap mean gene effect
-0.68
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FNTB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FNTB as an antibody target. Whether an autoantibody or antibody against FNTB could matter depends on whether native FNTB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FNTB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FNTB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FNTB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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