Seroatlas · Human Serome Atlas

PGGT1B

Geranylgeranyl transferase type-1 subunit beta

Also known as: BGGI, GGTI, PGTB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P53609
Gene
PGGT1B
Ensembl
ENSG00000164219
Chromosome
5
Canonical length
377 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>P53609|PGGT1B
     1  MAATEDERLA GSGEGERLDF LRDRHVRFFQ RCLQVLPERY SSLETSRLTI AFFALSGLDM
    61  LDSLDVVNKD DIIEWIYSLQ VLPTEDRSNL NRCGFRGSSY LGIPFNPSKA PGTAHPYDSG
   121  HIAMTYTGLS CLVILGDDLS RVNKEACLAG LRALQLEDGS FCAVPEGSEN DMRFVYCASC
   181  ICYMLNNWSG MDMKKAITYI RRSMSYDNGL AQGAGLESHG GSTFCGIASL CLMGKLEEVF
   241  SEKELNRIKR WCIMRQQNGY HGRPNKPVDT CYSFWVGATL KLLKIFQYTN FEKNRNYILS
   301  TQDRLVGGFA KWPDSHPDAL HAYFGICGLS LMEESGICKV HPALNVSTRT SERLLDLHQS
   361  WKTKDSKQCS ENVHIST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGGT1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 14 nTPM
  • colon: 14 nTPM
  • duodenum: 12 nTPM
  • bone marrow: 12 nTPM
  • liver: 12 nTPM
  • parathyroid gland: 12 nTPM

Single-cell type

  • microglia: 99 nCPM
  • rod photoreceptor cells: 95 nCPM
  • late primary spermatocytes: 59 nCPM
  • myonuclei: 58 nCPM
  • thyrotrophs: 56 nCPM
  • b-cells: 55 nCPM

Immune cell

  • eosinophil: 34 nTPM
  • non-classical monocyte: 27 nTPM
  • intermediate monocyte: 25 nTPM
  • neutrophil: 20 nTPM
  • classical monocyte: 19 nTPM
  • myeloid DC: 17 nTPM

Brain region

  • white matter: 20 nTPM
  • medulla oblongata: 19 nTPM
  • cerebellum: 18 nTPM
  • hypothalamus: 18 nTPM
  • basal ganglia: 18 nTPM
  • midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0.04
gnomAD missense Z
1.01
DepMap mean gene effect
-0.51
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PGGT1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PGGT1B as an antibody target. Whether an autoantibody or antibody against PGGT1B could matter depends on whether native PGGT1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PGGT1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PGGT1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PGGT1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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