WFDC2

Protein identityUniProt · HPA

UniProt accession

Q14508

Gene

WFDC2

Ensembl

ENSG00000101443

Chromosome

20

Canonical length

124 aa

Protein class

Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted in other tissues

Quaternary structure

Homotrimer

OverviewNCBI Gene

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>Q14508|WFDC2
     1  MPACRLGPLA AALLLSLLLF GFTLVSGTGA EKTGVCPELQ ADQNCTQECV SDSECADNLK
    61  CCSAGCATFC SLPNDKEGSC PQVNINFPQL GLCRDQCQVD SQCPGQMKCC RNGCGKVSCV
   121  TPNF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WFDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

4,906 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WFDC2.

Disease | AllUniProt

Conditions WFDC2 is implicated in, by any mechanism.

• Bronchiectasis and nasal polyposis (BENP) MIM:620984

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 34 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Bronchiectasis and nasal polyposis

ReferencesPubMed · IEDB

Publications for WFDC2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.57

gnomAD pLI

0.79

gnomAD missense Z

0.06

DepMap mean gene effect

-0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antibacterial humoral response
• innate immune response
• proteolysis
• spermatogenesis

Molecular functions

• aspartic-type endopeptidase inhibitor activity
• cysteine-type endopeptidase inhibitor activity
• endopeptidase inhibitor activity
• serine-type endopeptidase inhibitor activity

Cellular components

• extracellular exosome
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• WAP-type 'four-disulfide core' domain
• Elafin-like superfamily
• WAP four-disulfide core domain
• WAP-type (Whey Acidic Protein) 'four-disulfide core'

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Protease inhibitor
• Repeat
• Secreted
• Serine protease inhibitor
• Signal
• Thiol protease inhibitor
• Aspartic protease inhibitor

InteractionsUniProt · HPA

Protein binding partners of WFDC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FKBP7