Seroatlas · Human Serome Atlas

PTGER4

Prostaglandin E2 receptor EP4 subtype

Also known as: EP4, PE2R4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35408
Gene
PTGER4
Ensembl
ENSG00000171522
Chromosome
5
Canonical length
488 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>P35408|PTGER4
     1  MSTPGVNSSA SLSPDRLNSP VTIPAVMFIF GVVGNLVAIV VLCKSRKEQK ETTFYTLVCG
    61  LAVTDLLGTL LVSPVTIATY MKGQWPGGQP LCEYSTFILL FFSLSGLSII CAMSVERYLA
   121  INHAYFYSHY VDKRLAGLTL FAVYASNVLF CALPNMGLGS SRLQYPDTWC FIDWTTNVTA
   181  HAAYSYMYAG FSSFLILATV LCNVLVCGAL LRMHRQFMRR TSLGTEQHHA AAAASVASRG
   241  HPAASPALPR LSDFRRRRSF RRIAGAEIQM VILLIATSLV VLICSIPLVV RVFVNQLYQP
   301  SLEREVSKNP DLQAIRIASV NPILDPWIYI LLRKTVLSKA IEKIKCLFCR IGGSRRERSG
   361  QHCSDSQRTS SAMSGHSRSF ISRELKEISS TSQTLLPDLS LPDLSENGLG GRNLLPGVPG
   421  MGLAQEDTTS LRTLRISETS DSSQGQDSES VLLVDEAGGS GRAGPAPKGS SLQVTFPSET
   481  LNLSEKCI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGER4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
81 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 81 nTPM
  • pancreas: 51 nTPM
  • small intestine: 23 nTPM
  • duodenum: 19 nTPM
  • colon: 19 nTPM
  • stomach: 19 nTPM

Single-cell type

  • t-cells: 218 nCPM
  • innate lymphoid cells: 170 nCPM
  • podocytes: 144 nCPM
  • nk-cells: 136 nCPM
  • cdc: 136 nCPM
  • hematopoietic stem cells: 116 nCPM

Immune cell

  • non-classical monocyte: 25 nTPM
  • intermediate monocyte: 19 nTPM
  • gdT-cell: 16 nTPM
  • eosinophil: 15 nTPM
  • neutrophil: 13 nTPM
  • memory CD8 T-cell: 9.8 nTPM

Brain region

  • white matter: 6.9 nTPM
  • midbrain: 4.8 nTPM
  • medulla oblongata: 3.7 nTPM
  • spinal cord: 3.6 nTPM
  • pons: 3.3 nTPM
  • choroid plexus: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
2.21
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTGER4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTGER4 as an antibody target. Whether an autoantibody or antibody against PTGER4 could matter depends on whether native PTGER4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTGER4 is annotated at the cell surface, where native PTGER4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PTGER4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTGER4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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