Seroatlas · Human Serome Atlas

KDM8

Bifunctional peptidase and arginyl-hydroxylase JMJD5

Also known as: FLJ13798, JMJD5, KDM8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N371
Gene: KDM8
Ensembl: ENSG00000155666
Chromosome: 16
Canonical length: 416 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>Q8N371|KDM8
     1  MAGDTHCPAE PLAREGTLWE ALRALLPHSK EDLKLDLGEK VERSVVTLLQ RATELFYEGR
    61  RDECLQSSEV ILDYSWEKLN TGTWQDVDKD WRRVYAIGCL LKALCLCQAP EDANTVAAAL
   121  RVCDMGLLMG AAILGDILLK VAAILQTHLP GKRPARGSLP EQPCTKKARA DHGLIPDVKL
   181  EKTVPRLHRP SLQHFREQFL VPGRPVILKG VADHWPCMQK WSLEYIQEIA GCRTVPVEVG
   241  SRYTDEEWSQ TLMTVNEFIS KYIVNEPRDV GYLAQHQLFD QIPELKQDIS IPDYCSLGDG
   301  EEEEITINAW FGPQGTISPL HQDPQQNFLV QVMGRKYIRL YSPQESGALY PHDTHLLHNT
   361  SQVDVENPDL EKFPKFAKAP FLSCILSPGE ILFIPVKYWH YVRALDLSFS VSFWWS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KDM8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

liver: 78 nTPM
duodenum: 13 nTPM
small intestine: 12 nTPM
pancreas: 4.9 nTPM
spleen: 4.4 nTPM
skeletal muscle: 4.3 nTPM

Single-cell type

hepatocytes: 85 nCPM
enterocytes: 48 nCPM
myonuclei: 13 nCPM
cholangiocytes: 12 nCPM
epicardial cells: 11 nCPM
retinal bipolar cells: 11 nCPM

Immune cell

naive CD8 T-cell: 4.9 nTPM
naive B-cell: 4.3 nTPM
plasmacytoid DC: 4 nTPM
memory CD4 T-cell: 3.6 nTPM
memory CD8 T-cell: 3.5 nTPM
naive CD4 T-cell: 3.4 nTPM

Brain region

cerebellum: 9.8 nTPM
cerebral cortex: 7.3 nTPM
basal ganglia: 7.1 nTPM
hypothalamus: 7.1 nTPM
white matter: 7.1 nTPM
amygdala: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.61
DepMap mean gene effect: -0.51
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

aminopeptidase activity
chromatin binding
endopeptidase activity
histone H3K36 demethylase activity
metal ion binding
p53 binding
peptidyl-arginine 3-dioxygenase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

JmjC domain
Cupin-like domain 8
Cupin-like domain
KDM8, N-terminal
KDM8-like, N-terminal ARM repeats

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KDM8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KDM8 as an antibody target. Whether an autoantibody or antibody against KDM8 could matter depends on whether native KDM8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KDM8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KDM8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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