CUTA
Protein CutA
Also known as: ACHAP, C6orf82, CUTA_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O60888
- Gene
- CUTA
- Ensembl
- ENSG00000112514
- Chromosome
- 6
- Canonical length
- 179 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Plasma membrane,Focal adhesion sites
- Secretome location
- Secreted to blood
- Quaternary structure
- Homotrimer
OverviewNCBI Gene
Enables enzyme binding activity. Involved in protein localization. Located in membrane and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
179 residues, UniProt reviewed canonical sequence.
>O60888|CUTA
1 MSGGRAPAVL LGGVASLLLS FVWMPALLPV ASRLLLLPRV LLTMASGSPP TQPSPASDSG
61 SGYVPGSVSA AFVTCPNEKV AKEIARAVVE KRLAACVNLI PQITSIYEWK GKIEEDSEVL
121 MMIKTQSSLV PALTDFVRSV HPYEVAEVIA LPVEQGNFPY LQWVRQVTES VSDSITVLPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CUTA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 421 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 421 nTPM
- pituitary gland: 325 nTPM
- adrenal gland: 251 nTPM
- basal ganglia: 209 nTPM
- liver: 208 nTPM
- kidney: 196 nTPM
Single-cell type
- late spermatids: 484 nCPM
- decidual stromal cells: 474 nCPM
- epididymal efferent duct absorptive cells: 418 nCPM
- epididymal principal cells: 405 nCPM
- breast secretory cells: 354 nCPM
- parietal cells: 354 nCPM
Immune cell
- T-reg: 423 nTPM
- total PBMC: 401 nTPM
- naive CD4 T-cell: 368 nTPM
- memory CD4 T-cell: 362 nTPM
- MAIT T-cell: 336 nTPM
- memory B-cell: 317 nTPM
Brain region
- choroid plexus: 188 nTPM
- white matter: 136 nTPM
- hypothalamus: 133 nTPM
- pons: 131 nTPM
- cerebellum: 125 nTPM
- basal ganglia: 123 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.65
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.05
- DepMap mean gene effect
- -0.18
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Divalent ion tolerance protein, CutA
- Nitrogen regulatory PII-like, alpha/beta
- Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal
- CutA1 divalent ion tolerance protein
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CUTA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CUTA as an antibody target. Whether an autoantibody or antibody against CUTA could matter depends on whether native CUTA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CUTA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CUTA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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