Seroatlas · Human Serome Atlas

TASOR2

Protein TASOR 2

Also known as: bA318E3.2, C10orf18, FAM208B, FLJ20360, KIAA2006, TASO2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VWN6
Gene: TASOR2
Ensembl: ENSG00000108021
Chromosome: 10
Canonical length: 2430 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in negative regulation of gene expression, epigenetic. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2430 residues, UniProt reviewed canonical sequence.

>Q5VWN6|TASOR2
     1  MAPPAHKSIL ERSENVLMSP WKGKLIVQDR MLCDIALWST YGAMIPTQLP QELDFKYVMK
    61  VSSLKKRLPE AAFRKQNYLE EKVCFQDLCF NLYEVELSNR QGENIDKLTE CIKNKQLAII
   121  KCLEDRGFFI LLTSSALLSE PDFGGKQMGL HGLHLFRSPL STGVKDLKVE DDISMKVIPI
   181  LSTLNCALLE TKKSLPEERI HPNTLVKRHF QELYKADRSP SLSVAPQDRM KDPTFLGKLP
   241  SGFDLIPPAE KCPSESLTQL NSYFSDPSAY ILEVSTALDL LAEHPQSPCV SDGICDAGFS
   301  LVMTPDPEFL VSEAEVRKET ETKKDSEEML KAKKRVFPLS PASNLRVQPK RKASMPHMVQ
   361  SKKVNLCRPF PKRTASRADN SSDSPTTLKL VKGQFPQKRK RGAEVLTAQF VQKTKLDRKN
   421  QEAPISKDVP VPTNAKRARK QEKSPVKTVP RAKPPVKKSP QKQRVNIVKG NENPRNRKQL
   481  QPVKGETASK LQSEISRGCQ EDGISINSVQ PENTTAAHND LPENSIVNYD SQALNMLADL
   541  ALSSATSSTP VSEARNLHCS SELPQNDVLL SKENSLRGTS DHEYHRGVKT QKGELLPNPS
   601  SDRKSNSGSD LTVSQDEESL VPCSQAPAKA QSALTEEMLE SSDASQSSSV SVEHSYALLL
   661  TEHSKKHLQE REILSPLFPR NGTKSPEAAT PVGKVMPFRH QPGLLLQQKP PDDPVVKPKD
   721  RPPSARVKKS SCSRIVLSCD DSVKITFKCE TEYAFSLDSK YTNNPLEKTV VRALHGPWNT
   781  DLPDNVEEVK LLLHMWVALF YSNQNKIIRS SRKVVEHSNP AKYVSINSTL ESCELREIEE
   841  SLGLEKCSAD SLLETNEISR AHAAEVSFRD PNCLLPFIKT PLTQGLELCV QNEQKKTFAR
   901  ECDPDTQEDQ NFICSYNNEV TGEEAKQESL ETSNLVLSGI GSTQTNGPSV PSEEEIVQPL
   961  DSTRVASYSG TVTQATFTRT YDGPGSQPVI CQSSVYGTLE NKVDILDAAV QTKTGTLQDL
  1021  IQHGSPINNE CHPSLERKDD NMGCAVINPE PITLTFEKNA HVPIQTEGVN TADERTTFKK
  1081  ELIKQVSPAA SLRHPVSTSE NARTQGLRDI PSLVVAGQKG TKYLCASSVG GETLDKAVCS
  1141  LQKETPLPVS LPSDKTMVME ALSLAKSSSH LSPSEEVRCT QDFLSQTQSL LGLSSEGLLE
  1201  LTQVEVDSSS ASTTLGRQCS LNCISSGCHT SGDSLELRKN HKNGPNTENM NLEAFDSVFI
  1261  KQTSLSVSRE VSLELSEEDS DIDLALTISP PTSPREEMPA GEIEQFEEAP FSNLELQDVA
  1321  EEIGEPEEVA LTESREVSSA DNVSVYPSVS EEPVENKERK GDNLQPVTLI LSKENCTLEI
  1381  AEEINVTSDF PFDSVIEEVS PASSPEPPVP VKETRPYQAV TPCILKLHGT QCEKSNQISQ
  1441  CESEDLGITE KENVFVGPTH PVGQDNFTQV QQMQVSAEMP LILTDHPGRT GRPTLPGKVT
  1501  EEIVSSEHDE GLSFSGKVQC YGRELNQPAS AAKCTGDFSP SPEKLVKSGN PLQPVSIENR
  1561  NLDLKHLVLE SSEPPFGPRN VIENKSLSDT LVSTTAPSGI VNVSVKQQTS PKSSQNHLFP
  1621  GDLKTDEGIY LQVKSLTAAS VDGAYSTQGC MCSVVPTLCS SSDNATLTHY VRPINAEPVF
  1681  QAQEIPAGRM ASLLKNGEPE AELHKETTGP GTAGPQSNTT SSLKGERKAI HTLQDVSTCE
  1741  TKELLNVGVS SLCAGPYQNT ADTKENLSKE PLASFVSESF DTSVCGIATE HVEIENSGEG
  1801  LRAEAGSETL GRDGEVGVNS DMHYELSGDS DLDLLGDCRN PRLDLEDSYT LRGSYTRKKD
  1861  VPTDGYESSL NFHNNNQEDW GCSSWVPGME TSLPPGHWTA AVKKEEKCVP PYVQIRDLHG
  1921  ILRTYANFSI TKELKDTMRT SHGLRRHPSF SANCGLPSSW TSTWQVADDL TQNTLDLEYL
  1981  RFAHKLKQTI KNGDSQHSAS SANVFPKESP TQISIGAFPS TKISEAPFLH PAPRSRSPLL
  2041  VTVVESDPRP QGQPRRGYTA SSLDSSSSWR ERCSHNRDLR NSQRNHTVSF HLNKLKYNST
  2101  VKESRNDISL ILNEYAEFNK VMKNSNQFIF QDKELNDVSG EATAQEMYLP FPGRSASYED
  2161  IIIDVCTNLH VKLRSVVKEA CKSTFLFYLV ETEDKSFFVR TKNLLRKGGH TEIEPQHFCQ
  2221  AFHRENDTLI IIIRNEDISS HLHQIPSLLK LKHFPSVIFA GVDSPGDVLD HTYQELFRAG
  2281  GFVISDDKIL EAVTLVQLKE IIKILEKLNG NGRWKWLLHY RENKKLKEDE RVDSTAHKKN
  2341  IMLKSFQSAN IIELLHYHQC DSRSSTKAEI LKCLLNLQIQ HIDARFAVLL TDKPTIPREV
  2401  FENSGILVTD VNNFIENIEK IAAPFRSSYW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TASOR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
tonsil: 15 nTPM
urinary bladder: 14 nTPM
thyroid gland: 14 nTPM
lymph node: 14 nTPM
tongue: 13 nTPM

Single-cell type

sertoli cells: 380 nCPM
somatotrophs: 259 nCPM
lactotrophs: 236 nCPM
adrenal medulla cells: 213 nCPM
adrenal cortex cells: 211 nCPM
early primary spermatocytes: 208 nCPM

Immune cell

naive B-cell: 1.7 nTPM
naive CD8 T-cell: 1.4 nTPM
T-reg: 1.3 nTPM
classical monocyte: 1.2 nTPM
intermediate monocyte: 1.1 nTPM
plasmacytoid DC: 1.1 nTPM

Brain region

cerebellum: 80 nTPM
white matter: 61 nTPM
choroid plexus: 60 nTPM
hypothalamus: 59 nTPM
cerebral cortex: 59 nTPM
midbrain: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.31
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-macromolecule adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TASOR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TASOR2 as an antibody target. Whether an autoantibody or antibody against TASOR2 could matter depends on whether native TASOR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TASOR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TASOR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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