Seroatlas · Human Serome Atlas

EIF4E1B

Eukaryotic translation initiation factor 4E type 1B

Also known as: FLJ36951, I4E1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NMX2
Gene: EIF4E1B
Ensembl: ENSG00000175766
Chromosome: 5
Canonical length: 242 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 4F complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>A6NMX2|EIF4E1B
     1  MLAVEVSEAE GGIREWEEEE KEEEAAERTP TGEKSPNSPR TLLSLRGKAR TGGPMEVKLE
    61  LHPLQNRWAL WFFKNDRSRA WQDNLHLVTK VDTVEDFWAL YSHIQLASKL SSGCDYALFK
   121  DGIQPMWEDS RNKRGGRWLV SLAKQQRHIE LDRLWLETLL CLIGESFEEH SREVCGAVVN
   181  IRTKGDKIAV WTREAENQAG VLHVGRVYKE RLGLSPKTII GYQAHADTAT KSNSLAKNKF
   241  VV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF4E1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 4.4 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 4.4 nTPM
retina: 2.5 nTPM
cerebellum: 2 nTPM
amygdala: 1.7 nTPM
hypothalamus: 1.1 nTPM
epididymis: 1 nTPM

Single-cell type

oocytes: 92 nCPM
cone photoreceptor cells: 48 nCPM
rod photoreceptor cells: 40 nCPM
retinal ganglion cells: 27 nCPM
retinal bipolar cells: 26 nCPM
retinal amacrine cells: 24 nCPM

Immune cell

basophil: 0.1 nTPM
memory B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 7.1 nTPM
white matter: 4.6 nTPM
cerebellum: 3.7 nTPM
amygdala: 2.9 nTPM
pons: 2.9 nTPM
basal ganglia: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.62
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

eukaryotic translation initiation factor 4F complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF4E1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EIF4EBP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF4E1B as an antibody target. Whether an autoantibody or antibody against EIF4E1B could matter depends on whether native EIF4E1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF4E1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF4E1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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