Seroatlas · Human Serome Atlas

DSCC1

Sister chromatid cohesion protein DCC1

Also known as: DCC1, DCC1_HUMAN, hDCC1, MGC5528

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BVC3
Gene
DSCC1
Ensembl
ENSG00000136982
Chromosome
8
Canonical length
393 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>Q9BVC3|DSCC1
     1  MKRTRDEVDA TLQIAKLNAA ELLPAVHCLG FGPGASGAAA GDFCLLELEP TLCQQLEDGH
    61  SLVIRGDKDE QAVLCSKDKT YDLKIADTSN MLLFIPGCKT PDQLKKEDSH CNIIHTEIFG
   121  FSNNYWELRR RRPKLKKLKK LLMENPYEGP DSQKEKDSNS SKYTTEDLLD QIQASEEEIM
   181  TQLQVLNACK IGGYWRILEF DYEMKLLNHV TQLVDSESWS FGKVPLNTCL QELGPLEPEE
   241  MIEHCLKCYG KKYVDEGEVY FELDADKICR AAARMLLQNA VKFNLAEFQE VWQQSVPEGM
   301  VTSLDQLKGL ALVDRHSRPE IIFLLKVDDL PEDNQERFNS LFSLREKWTE EDIAPYIQDL
   361  CGEKQTIGAL LTKYSHSSMQ NGVKVYNSRR PIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DSCC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
9.2 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 9.2 nTPM
  • lymph node: 6.6 nTPM
  • bone marrow: 5.7 nTPM
  • tonsil: 5.3 nTPM
  • appendix: 3.5 nTPM
  • salivary gland: 3.5 nTPM

Single-cell type

  • oocytes: 78 nCPM
  • megakaryocyte progenitors: 48 nCPM
  • erythrocyte progenitors: 44 nCPM
  • differentiating spermatogonia: 34 nCPM
  • gastric progenitor cells: 23 nCPM
  • undifferentiated spermatogonia: 22 nCPM

Immune cell

  • gdT-cell: 0.9 nTPM
  • NK-cell: 0.8 nTPM
  • MAIT T-cell: 0.7 nTPM
  • memory B-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.4 nTPM
  • naive CD8 T-cell: 0.3 nTPM

Brain region

  • cerebellum: 3.2 nTPM
  • white matter: 2.4 nTPM
  • pons: 2.1 nTPM
  • basal ganglia: 2 nTPM
  • spinal cord: 2 nTPM
  • cerebral cortex: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0.01
gnomAD missense Z
1.17
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Sister chromatid cohesion protein Dcc1
  • Sister chromatid cohesion protein Dcc1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DSCC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DSCC1 as an antibody target. Whether an autoantibody or antibody against DSCC1 could matter depends on whether native DSCC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DSCC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DSCC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DSCC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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