Paired Homeobox Transcription Factors
IPR050649
Definition
The paired homeobox family of transcription factors is characterized by their involvement in a wide range of developmental processes across various tissues and organs. Members of this family play crucial roles in brain and spinal cord development, including neuronal proliferation, migration, differentiation, and axonal guidance. They are essential for the formation of sensory neuron projections, perception of pain, and the development of craniofacial structures, limbs, and skull. Some proteins within this family are involved in reproductive processes, spermatogenesis, and may regulate gene expression related to neurotransmitter pathways. Others contribute to the maintenance of specific cell phenotypes, such as noradrenergic neurons, and are implicated in processes like epithelial to mesenchymal transition (EMT) and cell cycle regulation during spermatogenesis. The family also includes proteins that regulate gene expression in the intestine and participate in vitamin A metabolism.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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