Seroatlas · Human Serome Atlas

DOCK10

Dedicator of cytokinesis protein 10

Also known as: DOC10_HUMAN, KIAA0694, ZIZ3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96BY6
Gene
DOCK10
Ensembl
ENSG00000135905
Chromosome
2
Canonical length
2186 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

2186 residues, UniProt reviewed canonical sequence.

>Q96BY6|DOCK10
     1  MAGERTRRFT RSLLRPGQAA ELRHSAASAA AVAVSSRQQQ RQEKPRLLEP LDYETVIEEL
    61  EKTYRNDPLQ DLLFFPSDDF SAATVSWDIR TLYSTVPEDA EHKAENLLVK EACKFYSSQW
   121  HVVNYKYEQY SGDIRQLPRA EYKPEKLPSH SFEIDHEDAD KDEDTTSHSS SKGGGGAGGT
   181  GVFKSGWLYK GNFNSTVNNT VTVRSFKKRY FQLTQLPDNS YIMNFYKDEK ISKEPKGCIF
   241  LDSCTGVVQN NRLRKYAFEL KMNDLTYFVL AAETESDMDE WIHTLNRILQ ISPEGPLQGR
   301  RSTELTDLGL DSLDNSVTCE CTPEETDSSE NNLHADFAKY LTETEDTVKT TRNMERLNLF
   361  SLDPDIDTLK LQKKDLLEPE SVIKPFEEKA AKRIMIICKA LNSNLQGCVT ENENDPITNI
   421  EPFFVSVALY DLRDSRKISA DFHVDLNHAA VRQMLLGASV ALENGNIDTI TPRQSEEPHI
   481  KGLPEEWLKF PKQAVFSVSN PHSEIVLVAK IEKVLMGNIA SGAEPYIKNP DSNKYAQKIL
   541  KSNRQFCSKL GKYRMPFAWA VRSVFKDNQG NVDRDSRFSP LFRQESSKIS TEDLVKLVSD
   601  YRRADRISKM QTIPGSLDIA VDNVPLEHPN CVTSSFIPVK PFNMMAQTEP TVEVEEFVYD
   661  STKYCRPYRV YKNQIYIYPK HLKYDSQKCF NKARNITVCI EFKNSDEESA KPLKCIYGKP
   721  GGPLFTSAAY TAVLHHSQNP DFSDEVKIEL PTQLHEKHHI LFSFYHVTCD INAKANAKKK
   781  EALETSVGYA WLPLMKHDQI ASQEYNIPIA TSLPPNYLSF QDSASGKHGG SDIKWVDGGK
   841  PLFKVSTFVV STVNTQDPHV NAFFQECQKR EKDMSQSPTS NFIRSCKNLL NVEKIHAIMS
   901  FLPIILNQLF KVLVQNEEDE ITTTVTRVLT DIVAKCHEEQ LDHSVQSYIK FVFKTRACKE
   961  RTVHEELAKN VTGLLKSNDS TTVKHVLKHS WFFFAIILKS MAQHLIDTNK IQLPRPQRFP
  1021  ESYQNELDNL VMVLSDHVIW KYKDALEETR RANHSVARFL KRCFTFMDRG YVFKMVNNYI
  1081  SMFSSGDLKT LCQYKFDFLQ EVCQHEHFIP LCLPIRSANI PDPLTPSEST QELHASDMPE
  1141  YSVTNEFCRK HFLIGILLRE VGFALQEDQD VRHLALAVLK NLMAKHSFDD RYREPRKQAQ
  1201  IASLYMPLYG MLLDNMPRIY LKDLYPFTVN TSNQGSRDDL STNGGFQSQT AIKHANSVDT
  1261  SFSKDVLNSI AAFSSIAIST VNHADSRASL ASLDSNPSTN EKSSEKTDNC EKIPRPLSLI
  1321  GSTLRFDKLD QAETRSLLMC FLHIMKTISY ETLIAYWQRA PSPEVSDFFS ILDVCLQNFR
  1381  YLGKRNIIRK IAAAFKFVQS TQNNGTLKGS NPSCQTSGLL SQWMHSTSSH EGHKQHRSQT
  1441  LPIIRGKNAL SNPKLLQMLD NTMTSNSNEI DIVHHVDTEA NIATEVCLTI LDLLSLFTQT
  1501  HQRQLQQCDC QNSLMKRVFD TYMLFFQVNQ SATALKHVFA SLRLFVCKFP SAFFQGPADL
  1561  CGSFCYEVLK CCNHRSRSTQ TEASALLYFF MRKNFEFNKQ KSIVRSHLQL IKAVSQLIAD
  1621  AGIGGSRFQH SLAITNNFAN GDKQMKNSNF PAEVKDLTKR IRTVLMATAQ MKEHEKDPEM
  1681  LVDLQYSLAN SYASTPELRR TWLESMAKIH ARNGDLSEAA MCYIHIAALI AEYLKRKGYW
  1741  KVEKICTASL LSEDTHPCDS NSLLTTPSGG SMFSMGWPAF LSITPNIKEE GAMKEDSGMQ
  1801  DTPYNENILV EQLYMCVEFL WKSERYELIA DVNKPIIAVF EKQRDFKKLS DLYYDIHRSY
  1861  LKVAEVVNSE KRLFGRYYRV AFYGQGFFEE EEGKEYIYKE PKLTGLSEIS QRLLKLYADK
  1921  FGADNVKIIQ DSNKVNPKDL DPKYAYIQVT YVTPFFEEKE IEDRKTDFEM HHNINRFVFE
  1981  TPFTLSGKKH GGVAEQCKRR TILTTSHLFP YVKKRIQVIS QSSTELNPIE VAIDEMSKKV
  2041  SELNQLCTME EVDMIRLQLK LQGSVSVKVN AGPMAYARAF LEETNAKKYP DNQVKLLKEI
  2101  FRQFADACGQ ALDVNERLIK EDQLEYQEEL RSHYKDMLSE LSTVMNEQIT GRDDLSKRGV
  2161  DQTCTRVISK ATPALPTVSI SSSAEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DOCK10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 35 nTPM
  • spinal cord: 34 nTPM
  • lymph node: 34 nTPM
  • thymus: 33 nTPM
  • appendix: 23 nTPM
  • tonsil: 23 nTPM

Single-cell type

  • oligodendrocytes: 2,022 nCPM
  • microglia: 1,041 nCPM
  • retinal horizontal cells: 809 nCPM
  • mast cells: 714 nCPM
  • t-cells: 650 nCPM
  • oligodendrocyte progenitor cells: 646 nCPM

Immune cell

  • NK-cell: 15 nTPM
  • non-classical monocyte: 12 nTPM
  • memory CD4 T-cell: 11 nTPM
  • naive CD4 T-cell: 10 nTPM
  • intermediate monocyte: 9.2 nTPM
  • memory CD8 T-cell: 9 nTPM

Brain region

  • white matter: 177 nTPM
  • medulla oblongata: 111 nTPM
  • basal ganglia: 104 nTPM
  • pons: 89 nTPM
  • hypothalamus: 84 nTPM
  • thalamus: 81 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0
gnomAD missense Z
1.88
DepMap mean gene effect
0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DOCK10 as an antibody target. Whether an autoantibody or antibody against DOCK10 could matter depends on whether native DOCK10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DOCK10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DOCK10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DOCK10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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