Seroatlas · Human Serome Atlas

CNEP1R1

Nuclear envelope phosphatase-regulatory subunit 1

Also known as: C16orf69, FLJ38101, NEP1-R1, NEPR1_HUMAN, TMEM188

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9A8
Gene: CNEP1R1
Ensembl: ENSG00000205423
Chromosome: 16
Canonical length: 125 aa
Protein class: Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a transmembrane protein that belongs to the Tmemb_18A family. A similar protein in yeast is a component of an endoplasmic reticulum-associated protein phosphatase complex and is thought to play a role in the synthesis of triacylglycerol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>Q8N9A8|CNEP1R1
     1  MNSLEQAEDL KAFERRLTEY IHCLQPATGR WRMLLIVVSV CTATGAWNWL IDPETQKVSF
    61  FTSLWNHPFF TISCITLIGL FFAGIHKRVV APSIIAARCR TVLAEYNMSC DDTGKLILKP
   121  RPHVQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNEP1R1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 22 nTPM
testis: 17 nTPM
placenta: 15 nTPM
tonsil: 14 nTPM
appendix: 13 nTPM
lymph node: 13 nTPM

Single-cell type

neutrophils: 88 nCPM
esophageal apical cells: 73 nCPM
extravillous trophoblasts: 41 nCPM
monocytes: 41 nCPM
kupffer cells: 35 nCPM
macrophages: 31 nCPM

Immune cell

neutrophil: 51 nTPM
non-classical monocyte: 36 nTPM
intermediate monocyte: 29 nTPM
classical monocyte: 21 nTPM
myeloid DC: 17 nTPM
basophil: 16 nTPM

Brain region

cerebellum: 21 nTPM
white matter: 21 nTPM
basal ganglia: 19 nTPM
thalamus: 19 nTPM
cerebral cortex: 18 nTPM
medulla oblongata: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.41
gnomAD missense Z: 1.85
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein phosphatase regulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nuclear envelope phosphatase-regulatory subunit 1
Transmembrane protein 188

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNEP1R1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CTDNEP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNEP1R1 as an antibody target. Whether an autoantibody or antibody against CNEP1R1 could matter depends on whether native CNEP1R1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNEP1R1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNEP1R1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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