Seroatlas · Human Serome Atlas

CSNK1G2

Casein kinase I isoform gamma-2

Also known as: CK1g2, KC1G2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78368
Gene: CSNK1G2
Ensembl: ENSG00000133275
Chromosome: 19
Canonical length: 415 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Enables protein serine/threonine kinase activity. Predicted to be involved in endocytosis; positive regulation of canonical Wnt signaling pathway; and signal transduction. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

415 residues, UniProt reviewed canonical sequence.

>P78368|CSNK1G2
     1  MDFDKKGGKG ETEEGRRMSK AGGGRSSHGI RSSGTSSGVL MVGPNFRVGK KIGCGNFGEL
    61  RLGKNLYTNE YVAIKLEPIK SRAPQLHLEY RFYKQLSATE GVPQVYYFGP CGKYNAMVLE
   121  LLGPSLEDLF DLCDRTFTLK TVLMIAIQLI TRMEYVHTKS LIYRDVKPEN FLVGRPGTKR
   181  QHAIHIIDFG LAKEYIDPET KKHIPYREHK SLTGTARYMS INTHLGKEQS RRDDLEALGH
   241  MFMYFLRGSL PWQGLKADTL KERYQKIGDT KRATPIEVLC ENFPEEMATY LRYVRRLDFF
   301  EKPDYDYLRK LFTDLFDRSG FVFDYEYDWA GKPLPTPIGT VHTDLPSQPQ LRDKTQPHSK
   361  NQALNSTNGE LNADDPTAGH SNAPITAPAE VEVADETKCC CFFKRRKRKS LQRHK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSNK1G2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 94 nTPM

Expression across tissuesHPA

Tissue

testis: 94 nTPM
spleen: 67 nTPM
cerebellum: 62 nTPM
lung: 52 nTPM
adrenal gland: 51 nTPM
cerebral cortex: 51 nTPM

Single-cell type

late spermatids: 1,151 nCPM
early spermatids: 333 nCPM
neutrophils: 157 nCPM
innate lymphoid cells: 75 nCPM
monocytes: 70 nCPM
pdcs: 67 nCPM

Immune cell

non-classical monocyte: 15 nTPM
neutrophil: 10 nTPM
intermediate monocyte: 5.8 nTPM
plasmacytoid DC: 5.4 nTPM
eosinophil: 4.8 nTPM
gdT-cell: 4.2 nTPM

Brain region

cerebellum: 62 nTPM
hippocampal formation: 61 nTPM
cerebral cortex: 60 nTPM
medulla oblongata: 59 nTPM
midbrain: 57 nTPM
amygdala: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 0.99
gnomAD missense Z: 2.8
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSNK1G2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSNK1G2 as an antibody target. Whether an autoantibody or antibody against CSNK1G2 could matter depends on whether native CSNK1G2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSNK1G2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSNK1G2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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