Seroatlas · Human Serome Atlas

THAP4

Peroxynitrite isomerase THAP4

Also known as: CGI-36, Nb(III), THAP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WY91
Gene
THAP4
Ensembl
ENSG00000176946
Chromosome
2
Canonical length
577 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables several functions, including heme binding activity; nitric oxide binding activity; and peroxynitrite isomerase activity. Involved in nitrate metabolic process and tyrosine metabolic process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

577 residues, UniProt reviewed canonical sequence.

>Q8WY91|THAP4
     1  MVICCAAVNC SNRQGKGEKR AVSFHRFPLK DSKRLIQWLK AVQRDNWTPT KYSFLCSEHF
    61  TKDSFSKRLE DQHRLLKPTA VPSIFHLTEK KRGAGGHGRT RRKDASKATG GVRGHSSAAT
   121  SRGAAGWSPS SSGNPMAKPE SRRLKQAALQ GEATPRAAQE AASQEQAQQA LERTPGDGLA
   181  TMVAGSQGKA EASATDAGDE SATSSIEGGV TDKSGISMDD FTPPGSGACK FIGSLHSYSF
   241  SSKHTRERPS VPREPIDRKR LKKDVEPSCS GSSLGPDKGL AQSPPSSSLT ATPQKPSQSP
   301  SAPPADVTPK PATEAVQSEH SDASPMSINE VILSASGACK LIDSLHSYCF SSRQNKSQVC
   361  CLREQVEKKN GELKSLRQRV SRSDSQVRKL QEKLDELRRV SVPYPSSLLS PSREPPKMNP
   421  VVEPLSWMLG TWLSDPPGAG TYPTLQPFQY LEEVHISHVG QPMLNFSFNS FHPDTRKPMH
   481  RECGFIRLKP DTNKVAFVSA QNTGVVEVEE GEVNGQELCI ASHSIARISF AKEPHVEQIT
   541  RKFRLNSEGK LEQTVSMATT TQPMTQHLHV TYKKVTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THAP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
115 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 115 nTPM
  • kidney: 104 nTPM
  • heart muscle: 100 nTPM
  • parathyroid gland: 100 nTPM
  • tongue: 85 nTPM
  • choroid plexus: 79 nTPM

Single-cell type

  • endometrial luminal cells: 103 nCPM
  • parietal cells: 96 nCPM
  • epididymal efferent duct ciliated cells: 83 nCPM
  • colonocytes: 81 nCPM
  • epididymal principal cells: 81 nCPM
  • esophageal suprabasal cells: 75 nCPM

Immune cell

  • T-reg: 53 nTPM
  • eosinophil: 40 nTPM
  • basophil: 31 nTPM
  • memory CD4 T-cell: 30 nTPM
  • MAIT T-cell: 29 nTPM
  • naive CD4 T-cell: 28 nTPM

Brain region

  • thalamus: 52 nTPM
  • midbrain: 50 nTPM
  • hypothalamus: 47 nTPM
  • pons: 47 nTPM
  • amygdala: 46 nTPM
  • choroid plexus: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.28
gnomAD missense Z
1.9
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of THAP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THAP4 as an antibody target. Whether an autoantibody or antibody against THAP4 could matter depends on whether native THAP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THAP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THAP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/THAP4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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