Seroatlas · Human Serome Atlas

TMEM205

Transmembrane protein 205

Also known as: MBC3205, TM205_HUMAN, UNQ501

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UW68
Gene: TMEM205
Ensembl: ENSG00000105518
Chromosome: 19
Canonical length: 189 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Nuclear membrane,Endoplasmic reticulum

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>Q6UW68|TMEM205
     1  MEEGGNLGGL IKMVHLLVLS GAWGMQMWVT FVSGFLLFRS LPRHTFGLVQ SKLFPFYFHI
    61  SMGCAFINLC ILASQHAWAQ LTFWEASQLY LLFLSLTLAT VNARWLEPRT TAAMWALQTV
   121  EKERGLGGEV PGSHQGPDPY RQLREKDPKY SALRQNFFRY HGLSSLCNLG CVLSNGLCLA
   181  GLALEIRSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM205 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 364 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 364 nTPM
liver: 262 nTPM
parathyroid gland: 197 nTPM
adrenal gland: 171 nTPM
pancreas: 146 nTPM
kidney: 131 nTPM

Single-cell type

late spermatids: 459 nCPM
early spermatids: 268 nCPM
gastric chief cells: 101 nCPM
endometrial secretory cells: 99 nCPM
hepatocytes: 87 nCPM
parietal cells: 85 nCPM

Immune cell

classical monocyte: 338 nTPM
myeloid DC: 209 nTPM
total PBMC: 176 nTPM
plasmacytoid DC: 151 nTPM
intermediate monocyte: 150 nTPM
memory B-cell: 113 nTPM

Brain region

choroid plexus: 133 nTPM
hypothalamus: 107 nTPM
white matter: 103 nTPM
hippocampal formation: 93 nTPM
pons: 89 nTPM
thalamus: 89 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0.03
gnomAD missense Z: 0.31
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

TMEM205-like
Transmembrane protein 205
Domain of unknown function (DUF4149)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM205 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

COMT

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM205 as an antibody target. Whether an autoantibody or antibody against TMEM205 could matter depends on whether native TMEM205 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM205 is annotated at the cell surface, where native TMEM205 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM205 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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