Seroatlas · Human Serome Atlas

DCAF4L2

DDB1- and CUL4-associated factor 4-like protein 2

Also known as: DC4L2_HUMAN, WDR21C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NA75
Gene: DCAF4L2
Ensembl: ENSG00000176566
Chromosome: 8
Canonical length: 395 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q8NA75|DCAF4L2
     1  MESKRPRLLE EADKQKKTVR VGLNAPSMLR KNQLGFLRFA NYCRIARELR VSCMQRKKVQ
    61  IHSWDPSSLA SDRFNRILAN TNTDQLFTVN QVEAGGSKYG IITMRGLTTP ELRVYPHKTL
   121  YVPNRKVNSM CWASLNHLDS HLLLCFVGLA DTPSCAVLLP ASLFIGSFPG MRRPGMLCSF
   181  QIPDAWSCAW SLSIHAYHSF STGLSQQVLL TNVVTGHQQS FGTSSDVLAQ QFAIMTPLLF
   241  NGCRSGEIFG IDLRCGNQGS GWKAICLSHD SAVTSLQILQ DGQFLVSSDM TGTIKLWDLR
   301  ATKCVTQYEG HVNNSAYLPV HVNEEEGVVA AVGQDCYTRI WSLRHGHLLT TIPSPYPASE
   361  NDIPSVAFSS RLGGFRGAPG LLMAVREDLY CFSYG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCAF4L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

differentiating spermatogonia: 81 nCPM
undifferentiated spermatogonia: 71 nCPM
early primary spermatocytes: 69 nCPM
late primary spermatocytes: 41 nCPM
oocytes: 23 nCPM
early spermatids: 8.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.2 nTPM
midbrain: 0.1 nTPM
white matter: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.09
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Cul4-RING E3 ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCAF4L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCAF4L2 as an antibody target. Whether an autoantibody or antibody against DCAF4L2 could matter depends on whether native DCAF4L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCAF4L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCAF4L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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