Seroatlas · Human Serome Atlas

HCST

Hematopoietic cell signal transducer

Also known as: DAP10, DKFZP586C1522, HCST_HUMAN, KAP10, PIK3AP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBK5
Gene: HCST
Ensembl: ENSG00000126264
Chromosome: 19
Canonical length: 93 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus,Vesicles,Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

93 residues, UniProt reviewed canonical sequence.

>Q9UBK5|HCST
     1  MIHLGHILFL LLLPVAAAQT TPGERSSLPA FYPGTSGSCS GCGSLSLPLL AGLVAADAVA
    61  SLLIVGAVFL CARPRRSPAQ EDGKVYINMP GRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HCST can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 239 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 239 nTPM
spleen: 113 nTPM
lymph node: 64 nTPM
thymus: 56 nTPM
appendix: 51 nTPM
choroid plexus: 50 nTPM

Single-cell type

hofbauer cells: 856 nCPM
nk-cells: 726 nCPM
t-cells: 546 nCPM
cdc: 396 nCPM
monocytes: 365 nCPM
platelets: 349 nCPM

Immune cell

gdT-cell: 1,588 nTPM
total PBMC: 1,424 nTPM
NK-cell: 1,295 nTPM
memory CD8 T-cell: 1,294 nTPM
MAIT T-cell: 1,175 nTPM
naive CD8 T-cell: 1,112 nTPM

Brain region

white matter: 28 nTPM
thalamus: 20 nTPM
medulla oblongata: 19 nTPM
spinal cord: 17 nTPM
hypothalamus: 17 nTPM
choroid plexus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Hematopoietic cell signal transducer
DAP10 membrane protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HCST in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HCST as an antibody target. Whether an autoantibody or antibody against HCST could matter depends on whether native HCST is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HCST is annotated at the cell surface, where native HCST is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HCST as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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