CLC

Protein identityUniProt · HPA

UniProt accession

Q05315

Gene

CLC

Ensembl

ENSG00000105205

Chromosome

19

Canonical length

142 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

142 residues, UniProt reviewed canonical sequence.

>Q05315|CLC
     1  MSLLPVPYTE AASLSTGSTV TIKGRPLACF LNEPYLQVDF HTEMKEESDI VFHFQVCFGR
    61  RVVMNSREYG AWKQQVESKN MPFQDGQEFE LSISVLPDKY QVMVNGQSSY TFDHRIKPEA
   121  VKMVQVWRDI SLTKFNVSYL KR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

427 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CLC.

Disease | ImmuneIEDB

Conditions an epitope on CLC was assayed in.

• rheumatoid arthritis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.75

gnomAD pLI

0

gnomAD missense Z

0.02

DepMap mean gene effect

0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of activated T cell proliferation
• regulation of T cell anergy
• regulation of T cell cytokine production
• T cell apoptotic process

Molecular functions

• carbohydrate binding
• identical protein binding

Cellular components

• cytosol
• extracellular matrix

Protein domainsUniProt · Pfam · InterPro

• Galectin, carbohydrate recognition domain
• Concanavalin A-like lectin/glucanase domain superfamily
• Galectin-like
• Galactoside-binding lectin

KeywordsUniProt

• Acetylation
• Cytoplasm
• Lectin

InteractionsUniProt · HPA

Protein binding partners of CLC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CEL
• SORL1