NDOR1

Protein identityUniProt · HPA

UniProt accession

Q9UHB4

Gene

NDOR1

Ensembl

ENSG00000188566

Chromosome

9

Canonical length

597 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Intermediate filaments,Cytosol

OverviewNCBI Gene

This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

597 residues, UniProt reviewed canonical sequence.

>Q9UHB4|NDOR1
     1  MPSPQLLVLF GSQTGTAQDV SERLGREARR RRLGCRVQAL DSYPVVNLIN EPLVIFVCAT
    61  TGQGDPPDNM KNFWRFIFRK NLPSTALCQM DFAVLGLGDS SYAKFNFVAK KLHRRLLQLG
   121  GSALLPVCLG DDQHELGPDA AVDPWLRDLW DRVLGLYPPP PGLTEIPPGV PLPSKFTLLF
   181  LQEAPSTGSE GQRVAHPGSQ EPPSESKPFL APMISNQRVT GPSHFQDVRL IEFDILGSGI
   241  SFAAGDVVLI QPSNSAAHVQ RFCQVLGLDP DQLFMLQPRE PDVSSPTRLP QPCSMRHLVS
   301  HYLDIASVPR RSFFELLACL SLHELEREKL LEFSSAQGQE ELFEYCNRPR RTILEVLCDF
   361  PHTAAAIPPD YLLDLIPVIR PRAFSIASSL LTHPSRLQIL VAVVQFQTRL KEPRRGLCSS
   421  WLASLDPGQG PVRVPLWVRP GSLAFPETPD TPVIMVGPGT GVAPFRAAIQ ERVAQGQTGN
   481  FLFFGCRWRD QDFYWEAEWQ ELEKRDCLTL IPAFSREQEQ KVYVQHRLRE LGSLVWELLD
   541  RQGAYFYLAG NAKSMPADVS EALMSIFQEE GGLCSPDAAA YLARLQQTRR FQTETWA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDOR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

15 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NDOR1.

Disease | AutoantibodyPubMed

Conditions in which antibodies against NDOR1 are reported. Each links to that disease's full target list.

• Ovarian Neoplasms 3

Showing 1 of 2 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for NDOR1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.08

gnomAD pLI

0

gnomAD missense Z

-0.61

DepMap mean gene effect

-0.67

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• electron transport chain
• iron-sulfur cluster assembly

Molecular functions

• electron transfer activity
• FAD binding
• flavin adenine dinucleotide binding
• FMN binding
• NADP binding
• NADPH binding
• NADPH-hemoprotein reductase activity
• oxidoreductase activity
• oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
• NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity

Cellular components

• cytoplasm
• cytosol
• intermediate filament cytoskeleton
• nucleoplasm
• perinuclear region of cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Flavodoxin-like
• Oxidoreductase FAD/NAD(P)-binding
• Flavoprotein pyridine nucleotide cytochrome reductase
• Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
• Flavodoxin/nitric oxide synthase
• FAD-binding domain, ferredoxin reductase-type
• Riboflavin synthase-like beta-barrel
• NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
• Flavoprotein-like superfamily
• Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
• Oxidoreductase NAD-binding domain
• Flavodoxin
• FAD binding domain
• NADPH-dependent diflavin oxidoreductase 1

KeywordsUniProt

• Cytoplasm
• FAD
• Flavoprotein
• FMN
• NADP
• Oxidoreductase

InteractionsUniProt · HPA

Protein binding partners of NDOR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CIAPIN1
• DCPS