Seroatlas · Human Serome Atlas

RIC3

Protein RIC-3

Also known as: AYST720, FLJ11608, PRO1385, RIC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z5B4
Gene
RIC3
Ensembl
ENSG00000166405
Chromosome
11
Canonical length
369 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Secretome location
Intracellular and membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the folding and assembly of these receptor subunits in the endoplasmic reticulum and expression on the cell surface. This protein contains an N-terminal transmembrane domain, a proline-rich spacer, and a cytosolic C-terminal coiled-coil domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>Q7Z5B4|RIC3
     1  MAYSTVQRVA LASGLVLALS LLLPKAFLSR GKRQEPPPTP EGKLGRFPPM MHHHQAPSDG
    61  QTPGARFQRS HLAEAFAKAK GSGGGAGGGG SGRGLMGQII PIYGFGIFLY ILYILFKLSK
   121  GKTTAEDGKC YTAMPGNTHR KITSFELAQL QEKLKETEAA MEKLINRVGP NGESRAQTVT
   181  SDQEKRLLHQ LREITRVMKE GKFIDRFSPE KEAEEAPYME DWEGYPEETY PIYDLSDCIK
   241  RRQETILVDY PDPKELSAEE IAERMGMIEE EESDHLGWES LPTDPRAQED NSVTSCDPKP
   301  ETCSCCFHED EDPAVLAENA GFSADSYPEQ EETTKEEWSQ DFKDEGLGIS TDKAYTGSML
   361  RKRNPQGLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • retina: 33 nTPM
  • cerebellum: 32 nTPM
  • pituitary gland: 29 nTPM
  • thyroid gland: 21 nTPM
  • ovary: 19 nTPM
  • cerebral cortex: 17 nTPM

Single-cell type

  • adrenal cortex cells: 201 nCPM
  • rod photoreceptor cells: 179 nCPM
  • lactotrophs: 166 nCPM
  • retinal bipolar cells: 164 nCPM
  • somatotrophs: 163 nCPM
  • sertoli cells: 148 nCPM

Immune cell

  • naive B-cell: 13 nTPM
  • memory B-cell: 12 nTPM
  • naive CD4 T-cell: 6.6 nTPM
  • naive CD8 T-cell: 5.8 nTPM
  • memory CD4 T-cell: 4.5 nTPM
  • basophil: 3.7 nTPM

Brain region

  • cerebellum: 39 nTPM
  • cerebral cortex: 35 nTPM
  • hypothalamus: 33 nTPM
  • basal ganglia: 28 nTPM
  • white matter: 26 nTPM
  • midbrain: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
gnomAD missense Z
-0.64
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Resistance to inhibitors of cholinesterase protein 3
  • Resistance to inhibitors of cholinesterase protein 3, N-terminal
  • Resistance to inhibitors of cholinesterase homologue 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIC3 as an antibody target. Whether an autoantibody or antibody against RIC3 could matter depends on whether native RIC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RIC3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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