Seroatlas · Human Serome Atlas

CEP15

Centrosomal protein 15

Also known as: C3orf14, CEP15_HUMAN, HT021

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBI5
Gene: CEP15
Ensembl: ENSG00000114405
Chromosome: 3
Canonical length: 128 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be located in cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>Q9HBI5|CEP15
     1  MTSLFAQEIR LSKRHEEIVS QRLMLLQQME NKLGDQHTEK ASQLQTVETA FKRNLSLLKD
    61  IEAAEKSLQT RIHPLPRPEV VSLETRYWAS VEEYIPKWEQ FLLGRAPYPF AVENQNEAEN
   121  TIQNEAQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 59 nTPM
amygdala: 56 nTPM
basal ganglia: 42 nTPM
hypothalamus: 42 nTPM
hippocampal formation: 40 nTPM
midbrain: 38 nTPM

Single-cell type

late primary spermatocytes: 196 nCPM
early primary spermatocytes: 159 nCPM
early spermatids: 130 nCPM
breast hormone-responsive cells: 122 nCPM
pancreatic islet cells: 99 nCPM
oocytes: 97 nCPM

Immune cell

non-classical monocyte: 28 nTPM
intermediate monocyte: 18 nTPM
basophil: 9.2 nTPM
T-reg: 7.9 nTPM
plasmacytoid DC: 7.6 nTPM
myeloid DC: 5.4 nTPM

Brain region

cerebral cortex: 39 nTPM
basal ganglia: 34 nTPM
hypothalamus: 34 nTPM
spinal cord: 27 nTPM
pons: 26 nTPM
hippocampal formation: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cilium

Protein domainsUniProt · Pfam · InterPro

Centrosomal protein 15-like
Centrosomal protein 15-like

KeywordsUniProt

Cell projection

InteractionsUniProt · HPA

Protein binding partners of CEP15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CEP89

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP15 as an antibody target. Whether an autoantibody or antibody against CEP15 could matter depends on whether native CEP15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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