Seroatlas · Human Serome Atlas

CENPT

Centromere protein T

Also known as: C16orf56, CENP-T, CENPT_HUMAN, FLJ13111

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96BT3
Gene
CENPT
Ensembl
ENSG00000102901
Chromosome
16
Canonical length
561 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

561 residues, UniProt reviewed canonical sequence.

>Q96BT3|CENPT
     1  MADHNPDSDS TPRTLLRRVL DTADPRTPRR PRSARAGARR ALLETASPRK LSGQTRTIAR
    61  GRSHGARSVG RSAHIQASGH LEEQTPRTLL KNILLTAPES SILMPESVVK PVPAPQAVQP
   121  SRQESSCGSL ELQLPELEPP TTLAPGLLAP GRRKQRLRLS VFQQGVDQGL SLSQEPQGNA
   181  DASSLTRSLN LTFATPLQPQ SVQRPGLARR PPARRAVDVG AFLRDLRDTS LAPPNIVLED
   241  TQPFSQPMVG SPNVYHSLPC TPHTGAEDAE QAAGRKTQSS GPGLQKNSPG KPAQFLAGEA
   301  EEVNAFALGF LSTSSGVSGE DEVEPLHDGV EEAEKKMEEE GVSVSEMEAT GAQGPSRVEE
   361  AEGHTEVTEA EGSQGTAEAD GPGASSGDED ASGRAASPES ASSTPESLQA RRHHQFLEPA
   421  PAPGAAVLSS EPAEPLLVRH PPRPRTTGPR PRQDPHKAGL SHYVKLFSFY AKMPMERKAL
   481  EMVEKCLDKY FQHLCDDLEV FAAHAGRKTV KPEDLELLMR RQGLVTDQVS LHVLVERHLP
   541  LEYRQLLIPC AYSGNSVFPA Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CENPT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • skin: 24 nTPM
  • testis: 19 nTPM
  • cerebellum: 13 nTPM
  • cerebral cortex: 9.7 nTPM
  • amygdala: 9.4 nTPM
  • pancreas: 9.2 nTPM

Single-cell type

  • platelets: 143 nCPM
  • late primary spermatocytes: 97 nCPM
  • early primary spermatocytes: 70 nCPM
  • late spermatids: 63 nCPM
  • epicardial cells: 55 nCPM
  • migrating cytotrophoblasts: 48 nCPM

Immune cell

  • T-reg: 8.6 nTPM
  • memory CD8 T-cell: 8.2 nTPM
  • classical monocyte: 7.2 nTPM
  • MAIT T-cell: 7 nTPM
  • naive CD8 T-cell: 7 nTPM
  • intermediate monocyte: 6.6 nTPM

Brain region

  • cerebral cortex: 8.5 nTPM
  • hypothalamus: 8.5 nTPM
  • pons: 8.2 nTPM
  • medulla oblongata: 8.1 nTPM
  • cerebellum: 7.6 nTPM
  • midbrain: 7.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CENPT.

Disease | AllUniProt

Conditions CENPT is implicated in, by any mechanism.

  • Short stature and microcephaly with genital anomalies (SSMGA) MIM:618702

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 149 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Short stature and microcephaly with genital anomalies

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0
gnomAD missense Z
0.14
DepMap mean gene effect
-0.57
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CENPT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CENPT as an antibody target. Whether an autoantibody or antibody against CENPT could matter depends on whether native CENPT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CENPT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CENPT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CENPT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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