Seroatlas · Human Serome Atlas

CENPW

Centromere protein W

Also known as: C6orf173, CENPW_HUMAN, CUG2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5EE01
Gene: CENPW
Ensembl: ENSG00000203760
Chromosome: 6
Canonical length: 88 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity and protein heterodimerization activity. Involved in chromosome segregation; kinetochore assembly; and mitotic cell cycle. Located in kinetochore and nucleoplasm. Part of inner kinetochore. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

88 residues, UniProt reviewed canonical sequence.

>Q5EE01|CENPW
     1  MALSTIVSQR KQIKRKAPRG FLKRVFKRKK PQLRLEKSGD LLVHLNCLLF VHRLAEESRT
    61  NACASKCRVI NKEHVLAAAK VILKKSRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CENPW can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 48 nTPM
testis: 37 nTPM
thymus: 25 nTPM
esophagus: 23 nTPM
tonsil: 19 nTPM
endometrium: 18 nTPM

Single-cell type

late primary spermatocytes: 499 nCPM
gastric progenitor cells: 277 nCPM
esophageal basal cells: 259 nCPM
early spermatids: 243 nCPM
extravillous trophoblasts: 183 nCPM
submucosal glandular cells: 122 nCPM

Immune cell

intermediate monocyte: 20 nTPM
plasmacytoid DC: 19 nTPM
classical monocyte: 17 nTPM
myeloid DC: 16 nTPM
non-classical monocyte: 14 nTPM
T-reg: 12 nTPM

Brain region

hippocampal formation: 7.3 nTPM
cerebral cortex: 6 nTPM
basal ganglia: 3.7 nTPM
white matter: 3.5 nTPM
amygdala: 2.8 nTPM
hypothalamus: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0.41
gnomAD missense Z: 0.75
DepMap mean gene effect: -1.66
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Histone-fold
Centromere protein W
Centromere Protein W/WIP1
CENP-W protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CENPW in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CENPW as an antibody target. Whether an autoantibody or antibody against CENPW could matter depends on whether native CENPW is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CENPW is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CENPW as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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