CREM
cAMP-responsive element modulator
Also known as: CREM_HUMAN, hCREM-2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q03060
- Gene
- CREM
- Ensembl
- ENSG00000095794
- Chromosome
- 10
- Canonical length
- 345 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Vesicles
OverviewNCBI Gene
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
345 residues, UniProt reviewed canonical sequence.
>Q03060|CREM
1 MTMETVESQH DGSITASLTE SKSAHVQTQT GQNSIPALAQ VSVAGSGTRR GSPAVTLVQL
61 PSGQTIHVQG VIQTPQPWVI QSSEIHTVQV AAIAETDESA ESEGVIDSHK RREILSRRPS
121 YRKILNELSS DVPGVPKIEE ERSEEEGTPP SIATMAVPTS IYQTSTGQYI AIAQGGTIQI
181 SNPGSDGVQG LQALTMTNSG APPPGATIVQ YAAQSADGTQ QFFVPGSQVV VQDEETELAP
241 SHMAAATGDM PTYQIRAPTA ALPQGVVMAA SPGSLHSPQQ LAEEATRKRE LRLMKNREAA
301 KECRRRKKEY VKCLESRVAV LEVQNKKLIE ELETLKDICS PKTDYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CREM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.62
- Highest tissue expression
- 194 nTPM
Expression across tissuesHPA
Tissue
- testis: 194 nTPM
- adrenal gland: 128 nTPM
- placenta: 94 nTPM
- pituitary gland: 57 nTPM
- urinary bladder: 56 nTPM
- liver: 56 nTPM
Single-cell type
- early spermatids: 2,296 nCPM
- late primary spermatocytes: 1,685 nCPM
- late spermatids: 1,025 nCPM
- t-cells: 873 nCPM
- pdcs: 804 nCPM
- neutrophils: 740 nCPM
Immune cell
- T-reg: 16 nTPM
- MAIT T-cell: 15 nTPM
- memory CD4 T-cell: 13 nTPM
- plasmacytoid DC: 12 nTPM
- eosinophil: 12 nTPM
- gdT-cell: 11 nTPM
Brain region
- hypothalamus: 51 nTPM
- choroid plexus: 42 nTPM
- medulla oblongata: 38 nTPM
- cerebral cortex: 36 nTPM
- pons: 36 nTPM
- thalamus: 36 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.48
- gnomAD pLI
- 0.51
- gnomAD missense Z
- 0.46
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cAMP/PKA signal transduction
- cell differentiation
- glycosphingolipid metabolic process
- negative regulation of transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase II
- regulation of DNA-templated transcription
- regulation of transcription by RNA polymerase II
- rhythmic process
- signal transduction
- spermatogenesis
Molecular functions
- cAMP response element binding protein binding
- DNA binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CREM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CREM as an antibody target. Whether an autoantibody or antibody against CREM could matter depends on whether native CREM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CREM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CREM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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