Seroatlas · Human Serome Atlas

SCIMP

SLP adapter and CSK-interacting membrane protein

Also known as: C17orf87, DTFT5783, FLJ32580, MGC163426, MGC163428, SCIMP_HUMAN, UNQ5783

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWF3
Gene: SCIMP
Ensembl: ENSG00000161929
Chromosome: 17
Canonical length: 145 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>Q6UWF3|SCIMP
     1  MDTFTVQDST AMSWWRNNFW IILAVAIIVV SVGLGLILYC VCKWQLRRGK KWEIAKPLKH
    61  KQVDEEKMYE NVLNESPVQL PPLPPRNWPS LEDSSPQEAP SQPPATYSLV NKVKNKKTVS
   121  IPSYIEPEDD YDDVEIPANT EKASF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCIMP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

spleen: 46 nTPM
tonsil: 42 nTPM
lymph node: 37 nTPM
appendix: 29 nTPM
lung: 15 nTPM
liver: 9.8 nTPM

Single-cell type

kupffer cells: 223 nCPM
b-cells: 130 nCPM
monocytes: 90 nCPM
macrophages: 68 nCPM
cardiomyocytes: 65 nCPM
cdc: 56 nCPM

Immune cell

non-classical monocyte: 267 nTPM
intermediate monocyte: 239 nTPM
memory B-cell: 146 nTPM
naive B-cell: 125 nTPM
classical monocyte: 111 nTPM
myeloid DC: 84 nTPM

Brain region

choroid plexus: 29 nTPM
cerebellum: 27 nTPM
cerebral cortex: 24 nTPM
medulla oblongata: 23 nTPM
midbrain: 21 nTPM
white matter: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

molecular adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Immune Signaling and Apoptosis Regulator
SLP adapter and CSK-interacting membrane protein
SCIMP protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCIMP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCIMP as an antibody target. Whether an autoantibody or antibody against SCIMP could matter depends on whether native SCIMP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCIMP is annotated at the cell surface, where native SCIMP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SCIMP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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