Seroatlas · Human Serome Atlas

LRRC46

Leucine-rich repeat-containing protein 46

Also known as: LRC46_HUMAN, MGC16309

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96FV0
Gene
LRRC46
Ensembl
ENSG00000141294
Chromosome
17
Canonical length
321 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear bodies,Plasma membrane,Primary cilium,Basal body

OverviewNCBI Gene

Predicted to be involved in sperm flagellum assembly. Predicted to act upstream of or within maintenance of cell number; single fertilization; and sperm flagellum assembly. Predicted to be active in sperm midpiece. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q96FV0|LRRC46
     1  MSGGKSAQGP EEGGVCITEA LITKRNLTFP EDGELSEKMF HTLDELQTVR LDREGITTIR
    61  NLEGLQNLHS LYLQGNKIQQ IENLACIPSL RFLSLAGNQI RQVENLLDLP CLQFLDLSEN
   121  LIETLKLDEF PQSLLILNLS GNSCTNQDGY RELVTEALPL LLDLDGQPVV ERWISDEEDE
   181  ASSDEEFPEL SGPFCSERGF LKELEQELSR HREHRQQTAL TEHLLRMEMQ PTLTDLPLLP
   241  GVPMAGDSSP SATPAQGEET VPEAVSSPQA SSPTKKPCSL IPRGHQSSFW GRKGARAATA
   301  PKASVAEAPS TTKTTAKRSK K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 74 nTPM
  • testis: 49 nTPM
  • choroid plexus: 17 nTPM
  • lung: 5 nTPM
  • hypothalamus: 4.2 nTPM
  • hippocampal formation: 3.5 nTPM

Single-cell type

  • fallopian tube ciliated cells: 393 nCPM
  • respiratory ciliated cells: 318 nCPM
  • late primary spermatocytes: 306 nCPM
  • epididymal efferent duct ciliated cells: 184 nCPM
  • endometrial ciliated cells: 171 nCPM
  • early spermatids: 127 nCPM

Immune cell

  • basophil: 1.3 nTPM
  • NK-cell: 0.8 nTPM
  • myeloid DC: 0.7 nTPM
  • eosinophil: 0.5 nTPM
  • intermediate monocyte: 0.5 nTPM
  • neutrophil: 0.5 nTPM

Brain region

  • midbrain: 14 nTPM
  • choroid plexus: 8.7 nTPM
  • medulla oblongata: 6.4 nTPM
  • spinal cord: 6.3 nTPM
  • pons: 4.2 nTPM
  • white matter: 3.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LRRC46.

Disease | ImmuneIEDB

Conditions an epitope on LRRC46 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
0.85
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC46 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC46 as an antibody target. Whether an autoantibody or antibody against LRRC46 could matter depends on whether native LRRC46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRC46. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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