Seroatlas · Human Serome Atlas

CAVIN2

Caveolae-associated protein 2

Also known as: cavin-2, CAVN2_HUMAN, PS-p68, SDPR, SDR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95810
Gene
CAVIN2
Ensembl
ENSG00000168497
Chromosome
2
Canonical length
425 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>O95810|CAVIN2
     1  MGEDAAQAEK FQHPGSDMRQ EKPSSPSPMP SSTPSPSLNL GNTEEAIRDN SQVNAVTVLT
    61  LLDKLVNMLD AVQENQHKME QRQISLEGSV KGIQNDLTKL SKYQASTSNT VSKLLEKSRK
   121  VSAHTRAVKE RMDRQCAQVK RLENNHAQLL RRNHFKVLIF QEENEIPASV FVKQPVSGAV
   181  EGKEELPDEN KSLEETLHTV DLSSDDDLPH DEEALEDSAE EKVEESRAEK IKRSSLKKVD
   241  SLKKAFSRQN IEKKMNKLGT KIVSVERREK IKKSLTSNHQ KISSGKSSPF KVSPLTFGRK
   301  KVREGESHAE NETKSEDLPS SEQMPNDQEE ESFAEGHSEA SLASALVEGE IAEEAAEKAT
   361  SRGSNSGMDS NIDLTIVEDE EEESVALEQA QKVRYEGSYA LTSEEAERSD GDPVQPAVLQ
   421  VHQTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAVIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
155 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 155 nTPM
  • spleen: 106 nTPM
  • heart muscle: 91 nTPM
  • lung: 89 nTPM
  • thyroid gland: 73 nTPM
  • colon: 67 nTPM

Single-cell type

  • platelets: 5,719 nCPM
  • megakaryocytes: 1,873 nCPM
  • lymphatic endothelial cells: 912 nCPM
  • mast cells: 414 nCPM
  • vascular endothelial cells: 354 nCPM
  • alveolar cells type 1: 343 nCPM

Immune cell

  • total PBMC: 121 nTPM
  • basophil: 49 nTPM
  • neutrophil: 24 nTPM
  • plasmacytoid DC: 3.1 nTPM
  • classical monocyte: 2.4 nTPM
  • myeloid DC: 2.3 nTPM

Brain region

  • thalamus: 30 nTPM
  • basal ganglia: 24 nTPM
  • pons: 24 nTPM
  • medulla oblongata: 23 nTPM
  • cerebral cortex: 22 nTPM
  • amygdala: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.7
gnomAD pLI
0
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAVIN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAVIN2 as an antibody target. Whether an autoantibody or antibody against CAVIN2 could matter depends on whether native CAVIN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAVIN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAVIN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAVIN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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