Seroatlas · Human Serome Atlas

ADRA1A

Alpha-1A adrenergic receptor

Also known as: ADA1A_HUMAN, ADRA1C, ADRA1L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35348
Gene
ADRA1A
Ensembl
ENSG00000120907
Chromosome
8
Canonical length
466 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

466 residues, UniProt reviewed canonical sequence.

>P35348|ADRA1A
     1  MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV
    61  THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII
   121  SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE
   181  EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN
   241  APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD
   301  FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL
   361  HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT
   421  TARVRSKSFL QVCCCVGPST PSLDKNHQVP TIKVHTISLS ENGEEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADRA1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • liver: 56 nTPM
  • adipose tissue: 21 nTPM
  • seminal vesicle: 13 nTPM
  • prostate: 12 nTPM
  • spleen: 8.6 nTPM
  • heart muscle: 7.2 nTPM

Single-cell type

  • hepatocytes: 604 nCPM
  • bergmann glia: 432 nCPM
  • adipocytes: 234 nCPM
  • smooth muscle cells: 205 nCPM
  • cardiomyocytes: 205 nCPM
  • oligodendrocyte progenitor cells: 192 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 109 nTPM
  • cerebral cortex: 67 nTPM
  • hypothalamus: 66 nTPM
  • amygdala: 48 nTPM
  • basal ganglia: 44 nTPM
  • medulla oblongata: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.39
gnomAD pLI
0
gnomAD missense Z
-0.01
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADRA1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADRA1A as an antibody target. Whether an autoantibody or antibody against ADRA1A could matter depends on whether native ADRA1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADRA1A is annotated at the cell surface, where native ADRA1A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADRA1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADRA1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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