CAMK1D

Protein identityUniProt · HPA

UniProt accession

Q8IU85

Gene

CAMK1D

Ensembl

ENSG00000183049

Chromosome

10

Canonical length

385 aa

Protein class

Enzymes, Plasma proteins, Predicted membrane proteins

Subcellular location

Nucleoplasm,Basal body,Cytosol

OverviewNCBI Gene

This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

385 residues, UniProt reviewed canonical sequence.

>Q8IU85|CAMK1D
     1  MARENGESSS SWKKQAEDIK KIFEFKETLG TGAFSEVVLA EEKATGKLFA VKCIPKKALK
    61  GKESSIENEI AVLRKIKHEN IVALEDIYES PNHLYLVMQL VSGGELFDRI VEKGFYTEKD
   121  ASTLIRQVLD AVYYLHRMGI VHRDLKPENL LYYSQDEESK IMISDFGLSK MEGKGDVMST
   181  ACGTPGYVAP EVLAQKPYSK AVDCWSIGVI AYILLCGYPP FYDENDSKLF EQILKAEYEF
   241  DSPYWDDISD SAKDFIRNLM EKDPNKRYTC EQAARHPWIA GDTALNKNIH ESVSAQIRKN
   301  FAKSKWRQAF NATAVVRHMR KLHLGSSLDS SNASVSSSLS LASQKDCLAP STLCSFISSS
   361  SGVSGVGAER RPRPTTVTAV HSGSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAMK1D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

54 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CAMK1D.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 55 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.23

gnomAD pLI

1

gnomAD missense Z

2.49

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• inflammatory response
• negative regulation of apoptotic process
• nervous system development
• positive regulation of apoptotic process
• positive regulation of CREB transcription factor activity
• positive regulation of neuron projection development
• positive regulation of neutrophil chemotaxis
• positive regulation of phagocytosis
• positive regulation of respiratory burst
• regulation of dendrite development
• regulation of neuron projection development
• signal transduction
• regulation of granulocyte chemotaxis

Molecular functions

• ATP binding
• calcium/calmodulin-dependent protein kinase activity
• calmodulin binding
• protein serine kinase activity

Cellular components

• cytoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• Protein kinase domain

KeywordsUniProt

• Allosteric enzyme
• ATP-binding
• Calcium
• Calmodulin-binding
• Cytoplasm
• Inflammatory response
• Isopeptide bond
• Kinase
• Neurogenesis
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Serine/threonine-protein kinase
• Transferase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of CAMK1D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CAMK1