Seroatlas · Human Serome Atlas

TRMT112

Multifunctional methyltransferase subunit TRM112-like protein

Also known as: HSPC152, HSPC170, hTrm112, TR112_HUMAN, TRM112, TRMT11-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UI30
Gene: TRMT112
Ensembl: ENSG00000173113
Chromosome: 11
Canonical length: 125 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Microtubules

OverviewNCBI Gene

Enables protein heterodimerization activity; protein methyltransferase activity; and tRNA methyltransferase activator activity. Involved in macromolecule methylation and positive regulation of macromolecule metabolic process. Located in nucleoplasm and perinuclear region of cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>Q9UI30|TRMT112
     1  MKLLTHNLLS SHVRGVGSRG FPLRLQATEV RICPVEFNPN FVARMIPKVE WSAFLEAADN
    61  LRLIQVPKGP VEGYEENEEF LRTMHHLLLE VEVIEGTLQC PESGRMFPIS RGIPNMLLSE
   121  EETES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRMT112 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 247 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 247 nTPM
adrenal gland: 230 nTPM
ovary: 189 nTPM
kidney: 157 nTPM
pituitary gland: 155 nTPM
blood vessel: 153 nTPM

Single-cell type

oocytes: 1,151 nCPM
migrating cytotrophoblasts: 649 nCPM
differentiating spermatogonia: 623 nCPM
esophageal basal cells: 609 nCPM
cytotrophoblasts: 584 nCPM
esophageal suprabasal cells: 514 nCPM

Immune cell

memory B-cell: 807 nTPM
total PBMC: 804 nTPM
basophil: 709 nTPM
naive B-cell: 705 nTPM
plasmacytoid DC: 619 nTPM
naive CD4 T-cell: 525 nTPM

Brain region

choroid plexus: 88 nTPM
hypothalamus: 84 nTPM
white matter: 83 nTPM
midbrain: 78 nTPM
pons: 75 nTPM
medulla oblongata: 70 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0.14
gnomAD missense Z: -0.93
DepMap mean gene effect: -1.78
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein heterodimerization activity
protein methyltransferase activity
tRNA methyltransferase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Trm112-like
Trm112p-like protein
Multifunctional methyltransferase subunit Trm112

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRMT112 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRMT112 as an antibody target. Whether an autoantibody or antibody against TRMT112 could matter depends on whether native TRMT112 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRMT112 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRMT112 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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