BNIPL
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein
Also known as: BNIP-S, BNIP-Salpha, BNIP-Sbeta, BNIPL_HUMAN, BNIPl-1, BNIPL-2, PP753
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q7Z465
- Gene
- BNIPL
- Ensembl
- ENSG00000163141
- Chromosome
- 1
- Canonical length
- 357 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Canonical amino-acid sequenceUniProt
357 residues, UniProt reviewed canonical sequence.
>Q7Z465|BNIPL
1 MGTIQEAGKK TDVGVREIAE APELGAALRH GELELKEEWQ DEEFPRLLPE EAGTSEDPED
61 PKGDSQAAAG TPSTLALCGQ RPMRKRLSAP ELRLSLTKGP GNDGASPTQS APSSPDGSSD
121 LEIDELETPS DSEQLDSGHE FEWEDELPRA EGLGTSETAE RLGRGCMWDV TGEDGHHWRV
181 FRMGPREQRV DMTVIEPYKK VLSHGGYHGD GLNAVILFAS CYLPRSSIPN YTYVMEHLFR
241 YMVGTLELLV AENYLLVHLS GGTSRAQVPP LSWIRQCYRT LDRRLRKNLR ALVVVHATWY
301 VKAFLALLRP FISSKFTRKI RFLDSLGELA QLISLDQVHI PEAVRQLDRD LHGSGGTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against BNIPL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 171 nTPM
Expression across tissuesHPA
Tissue
- skin: 171 nTPM
- esophagus: 118 nTPM
- vagina: 65 nTPM
- cervix: 50 nTPM
- salivary gland: 20 nTPM
- breast: 15 nTPM
Single-cell type
- esophageal apical cells: 1,259 nCPM
- esophageal suprabasal cells: 351 nCPM
- suprabasal keratinocytes: 146 nCPM
- prostatic hillock cells: 93 nCPM
- salivary duct cells: 85 nCPM
- prostatic club cells: 74 nCPM
Immune cell
- neutrophil: 0.6 nTPM
- basophil: 0.5 nTPM
- gdT-cell: 0.3 nTPM
- MAIT T-cell: 0.2 nTPM
- memory CD4 T-cell: 0.2 nTPM
- memory CD8 T-cell: 0.2 nTPM
Brain region
- cerebellum: 7.5 nTPM
- medulla oblongata: 4.6 nTPM
- cerebral cortex: 4 nTPM
- hypothalamus: 3.8 nTPM
- pons: 3.8 nTPM
- midbrain: 3.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.2
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.92
- DepMap mean gene effect
- -0.22
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of BNIPL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads BNIPL as an antibody target. Whether an autoantibody or antibody against BNIPL could matter depends on whether native BNIPL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
BNIPL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label BNIPL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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