OMP
Olfactory marker protein
Also known as: OMP_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P47874
- Gene
- OMP
- Ensembl
- ENSG00000254550
- Chromosome
- 11
- Canonical length
- 163 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Olfactory marker protein is uniquely associated with the mature olfactory receptor neurons in many vertebrate species from fish to man. The OMP gene structure and protein sequence are highly conserved between mouse, rat and human. Results of the mouse knockout studies show that OMP-null mice are compromised in their ability to respond to odor stimuli, and that OMP represents a novel modulatory component of the odor detection/signal transduction cascade. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
163 residues, UniProt reviewed canonical sequence.
>P47874|OMP
1 MAEDRPQQPQ LDMPLVLDQG LTRQMRLRVE SLKQRGEKRQ DGEKLLQPAE SVYRLNFTQQ
61 QRLQFERWNV VLDKPGKVTI TGTSQNWTPD LTNLMTRQLL DPTAIFWRKE DSDAIDWNEA
121 DALEFGERLS DLAKIRKVMY FLVTFGEGVE PANLKASVVF NQLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OMP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 2.5 nTPM
Expression across tissuesHPA
Tissue
- duodenum: 2.5 nTPM
- small intestine: 2.4 nTPM
- rectum: 1.7 nTPM
- colon: 1.4 nTPM
- liver: 1.3 nTPM
- bone marrow: 1.1 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- pons: 4.2 nTPM
- cerebellum: 3.6 nTPM
- medulla oblongata: 3.4 nTPM
- hypothalamus: 2.8 nTPM
- cerebral cortex: 2.6 nTPM
- amygdala: 2.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.8
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.17
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Olfactory marker protein
- Olfactory marker superfamily
- Olfactory marker protein
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of OMP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OMP as an antibody target. Whether an autoantibody or antibody against OMP could matter depends on whether native OMP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OMP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label OMP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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