Seroatlas · Human Serome Atlas

RER1

Protein RER1

Also known as: RER1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15258
Gene: RER1
Ensembl: ENSG00000157916
Chromosome: 1
Canonical length: 196 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is a multi-pass membrane protein that is localized to the golgi apparatus. It is involved in the retention of endoplasmic reticulum (ER) membrane proteins in the ER and retrieval of ER membrane proteins from the early Golgi compartment to facilitate gamma-secretase complex assembly. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>O15258|RER1
     1  MSEGDSVGES VHGKPSVVYR FFTRLGQIYQ SWLDKSTPYT AVRWVVTLGL SFVYMIRVYL
    61  LQGWYIVTYA LGIYHLNLFI AFLSPKVDPS LMEDSDDGPS LPTKQNEEFR PFIRRLPEFK
   121  FWHAATKGIL VAMVCTFFDA FNVPVFWPIL VMYFIMLFCI TMKRQIKHMI KYRYIPFTHG
   181  KRRYRGKEDA GKAFAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RER1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 206 nTPM

Expression across tissuesHPA

Tissue

liver: 206 nTPM
esophagus: 168 nTPM
adrenal gland: 147 nTPM
rectum: 142 nTPM
tonsil: 134 nTPM
colon: 129 nTPM

Single-cell type

esophageal apical cells: 1,550 nCPM
late spermatids: 653 nCPM
syncytiotrophoblasts: 612 nCPM
late primary spermatocytes: 594 nCPM
esophageal suprabasal cells: 430 nCPM
early spermatids: 429 nCPM

Immune cell

neutrophil: 354 nTPM
total PBMC: 310 nTPM
eosinophil: 286 nTPM
non-classical monocyte: 278 nTPM
intermediate monocyte: 269 nTPM
plasmacytoid DC: 257 nTPM

Brain region

choroid plexus: 103 nTPM
white matter: 94 nTPM
thalamus: 85 nTPM
medulla oblongata: 81 nTPM
cerebellum: 79 nTPM
basal ganglia: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.38
gnomAD missense Z: 2.13
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

acetylcholine receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Retrieval of early ER protein Rer1
Rer1 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RER1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ATP5PO

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RER1 as an antibody target. Whether an autoantibody or antibody against RER1 could matter depends on whether native RER1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RER1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RER1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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