Seroatlas · Human Serome Atlas

TUNAR

Protein TUNAR

Also known as: BNLN, HI-LNC78, LINC00617, TUNA, TUNAR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTB2
Gene
TUNAR
Ensembl
ENSG00000250366
Chromosome
14
Canonical length
48 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Enables ATPase binding activity. Involved in endoplasmic reticulum calcium ion homeostasis and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

48 residues, UniProt reviewed canonical sequence.

>A0A1B0GTB2|TUNAR
     1  MVITSENDED RGGQEKESKE ESVLAMLGII GTILNLIVII FVYIYTTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUNAR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 48 nTPM
  • cerebral cortex: 15 nTPM
  • hypothalamus: 12 nTPM
  • hippocampal formation: 11 nTPM
  • fallopian tube: 8 nTPM
  • retina: 7.9 nTPM

Single-cell type

  • pancreatic islet cells: 48 nCPM
  • endometrial luminal cells: 40 nCPM
  • retinal amacrine cells: 24 nCPM
  • brain inhibitory neurons: 20 nCPM
  • oocytes: 14 nCPM
  • other brain neurons: 13 nCPM

Immune cell

  • naive B-cell: 0.3 nTPM
  • basophil: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • basal ganglia: 96 nTPM
  • pons: 72 nTPM
  • thalamus: 56 nTPM
  • medulla oblongata: 36 nTPM
  • midbrain: 33 nTPM
  • spinal cord: 32 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • TUNAR
  • TUNAR

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUNAR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUNAR as an antibody target. Whether an autoantibody or antibody against TUNAR could matter depends on whether native TUNAR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUNAR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUNAR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TUNAR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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