Seroatlas · Human Serome Atlas

ARL14EP

ARL14 effector protein

Also known as: AL14E_HUMAN, ARF7EP, C11orf46, FLJ38968

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N8R7
Gene
ARL14EP
Ensembl
ENSG00000152219
Chromosome
11
Canonical length
260 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Focal adhesion sites,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is an effector protein. It interacts with ADP-ribosylation factor-like 14 [ARL14, also known as ADP-ribosylation factor 7 (ARF7)], beta-actin (ACTB) and actin-based motor protein myosin 1E (MYO1E). ARL14 is a small GTPase; it controls the export of major histocompatibility class II molecules by connecting to the actin network via this effector protein. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

260 residues, UniProt reviewed canonical sequence.

>Q8N8R7|ARL14EP
     1  MMDPCSVGVQ LRTTNECHKT YYTRHTGFKT LQELSSNDML LLQLRTGMTL SGNNTICFHH
    61  VKIYIDRFED LQKSCCDPFN IHKKLAKKNL HVIDLDDATF LSAKFGRQLV PGWKLCPKCT
   121  QIINGSVDVD TEDRQKRKPE SDGRTAKALR SLQFTNPGRQ TEFAPETGKR EKRRLTKNAT
   181  AGSDRQVIPA KSKVYDSQGL LIFSGMDLCD CLDEDCLGCF YACPACGSTK CGAECRCDRK
   241  WLYEQIEIEG GEIIHNKHAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL14EP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 25 nTPM
  • thyroid gland: 23 nTPM
  • epididymis: 22 nTPM
  • heart muscle: 21 nTPM
  • adrenal gland: 21 nTPM
  • lymph node: 21 nTPM

Single-cell type

  • late primary spermatocytes: 206 nCPM
  • oocytes: 129 nCPM
  • early spermatids: 118 nCPM
  • late spermatids: 78 nCPM
  • corticotrophs: 62 nCPM
  • early primary spermatocytes: 60 nCPM

Immune cell

  • MAIT T-cell: 56 nTPM
  • NK-cell: 53 nTPM
  • memory B-cell: 36 nTPM
  • naive B-cell: 29 nTPM
  • memory CD4 T-cell: 28 nTPM
  • myeloid DC: 26 nTPM

Brain region

  • cerebral cortex: 24 nTPM
  • cerebellum: 23 nTPM
  • basal ganglia: 23 nTPM
  • hippocampal formation: 22 nTPM
  • choroid plexus: 22 nTPM
  • hypothalamus: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARL14EP.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 38 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0.38
gnomAD missense Z
0.63
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARL14EP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL14EP as an antibody target. Whether an autoantibody or antibody against ARL14EP could matter depends on whether native ARL14EP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL14EP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARL14EP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARL14EP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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