Seroatlas · Human Serome Atlas

ATF7IP2

Activating transcription factor 7-interacting protein 2

Also known as: FLJ12668, MCAF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5U623
Gene: ATF7IP2
Ensembl: ENSG00000166669
Chromosome: 16
Canonical length: 682 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

682 residues, UniProt reviewed canonical sequence.

>Q5U623|ATF7IP2
     1  MASPDRSKRK ILKAKKTMPL SCRKQVEMLN KSRNVEALKT AIGSNVPSGN QSFSPSVITR
    61  TTEITKCSPS ENGASSLDSN KNSISEKSKV FSQNCIKPVE EIVHSETKLE QVVCSYQKPS
   121  RTTESPSRVF TEEAKDSLNT SENDSEHQTN VTRSLFEHEG ACSLKSSCCP PSVLSGVVQM
   181  PESTVTSTVG DKKTDQMVFH LETNSNSESH DKRQSDNILC SEDSGFVPVE KTPNLVNSVT
   241  SNNCADDILK TDECSRTSIS NCESADSTWQ SSLDTNNNSH YQKKRMFSEN EENVKRMKTS
   301  EQINENICVS LERQTAFLEQ VRHLIQQEIY SINYELFDKK LKELNQRIGK TECRNKHEGI
   361  ADKLLAKIAK LQRRIKTVLL FQRNCLKPNM LSSNGASKVA NSEAMILDKN LESVNSPIEK
   421  SSVNYEPSNP SEKGSKKINL SSDQNKSVSE SNNDDVMLIS VESPNLTTPI TSNPTDTRKI
   481  TSGNSSNSPN AEVMAVQKKL DSIIDLTKEG LSNCNTESPV SPLESHSKAA SNSKETTPLA
   541  QNAVQVPESF EHLPPLPEPP APLPELVDKT RDTLPPQKPE LKVKRVFRPN GIALTWNITK
   601  INPKCAPVES YHLFLCHENS NNKLIWKKIG EIKALPLPMA CTLSQFLASN RYYFTVQSKD
   661  IFGRYGPFCD IKSIPGFSEN LT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATF7IP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

testis: 17 nTPM
thymus: 8.5 nTPM
liver: 8 nTPM
tonsil: 6.9 nTPM
lymph node: 6.7 nTPM
adrenal gland: 6 nTPM

Single-cell type

sertoli cells: 1,021 nCPM
epididymal principal cells: 601 nCPM
parietal cells: 469 nCPM
adrenal cortex cells: 289 nCPM
cardiomyocytes: 267 nCPM
early primary spermatocytes: 261 nCPM

Immune cell

MAIT T-cell: 10 nTPM
T-reg: 6.1 nTPM
gdT-cell: 4.2 nTPM
memory CD4 T-cell: 4.1 nTPM
memory CD8 T-cell: 3.9 nTPM
naive CD8 T-cell: 3.9 nTPM

Brain region

cerebral cortex: 9.3 nTPM
hippocampal formation: 8.4 nTPM
white matter: 8 nTPM
amygdala: 7.6 nTPM
hypothalamus: 6.9 nTPM
basal ganglia: 6.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.16
gnomAD missense Z: -1.32
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

transcription coregulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATF7IP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATF7IP2 as an antibody target. Whether an autoantibody or antibody against ATF7IP2 could matter depends on whether native ATF7IP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATF7IP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATF7IP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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