Seroatlas · Human Serome Atlas

ZNF48

Zinc finger protein 48

Also known as: DKFZp762K013, FLJ31751, MGC43952, ZNF48_HUMAN, ZNF553

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MX3
Gene: ZNF48
Ensembl: ENSG00000180035
Chromosome: 16
Canonical length: 618 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Mitochondria

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

618 residues, UniProt reviewed canonical sequence.

>Q96MX3|ZNF48
     1  MERAVEPWGP DLHRPEEREP QRGARTGLGS ENVISQPNEF EHTPQEDDLG FKEEDLAPDH
    61  EVGNASLKPE GIQNWDDLWV QREGLGKPQP RDRGPRLLGE PRWGQASSDR AAVCGECGKS
   121  FRQMSDLVKH QRTHTGEKPY KCGVCGKGFG DSSARIKHQR THSGEKPYRA RPPAQGPPKI
   181  PRSRIPAGER PTICGECGKS FRQSSDLVKH QRTHTGEKPY KCGICGKGFG DSSARIKHQR
   241  THRGEQPPRP VVPRRQPSRA ATAATQGPKA QDKPYICTDC GKRFVLSCSL LSHQRSHLGP
   301  KPFGCDVCGK EFARGSDLVK HLRVHTGEKP YLCPECGKGF ADSSARVKHL RTHSGERPHA
   361  CPECDRTFSL SSTLLRHRLT HMEPQDFSFP GYPLPALIPS PPPPPLGTSP PLTPRSPSHS
   421  GEPFGLPGLE PEPGGPQAGE PPPPLAGDKP HKCPECGKGF RRSSDLVKHH RVHTGEKPYL
   481  CPECGKGFAD SSARVKHLRT HRGERARPPP PSTLLRPHNP PGPVPMAPRP RVRAQPSGPS
   541  QPHVCGFCGK EFPRSSDLVK HRRTHTGEKP YKCAECGKGF GDSSARIKHQ RGHLVLTPFG
   601  IGDGRARPLK QEAATGLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF48 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 8.7 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 8.7 nTPM
cerebral cortex: 8.6 nTPM
colon: 7.6 nTPM
thymus: 7.6 nTPM
endometrium: 6.9 nTPM
parathyroid gland: 6.1 nTPM

Single-cell type

retinal pigment epithelial cells: 21 nCPM
cardiomyocytes: 18 nCPM
thymocytes: 17 nCPM
mast cells: 17 nCPM
oocytes: 14 nCPM
smooth muscle cells: 14 nCPM

Immune cell

gdT-cell: 0.9 nTPM
NK-cell: 0.9 nTPM
MAIT T-cell: 0.6 nTPM
naive CD8 T-cell: 0.6 nTPM
memory CD8 T-cell: 0.5 nTPM
naive CD4 T-cell: 0.5 nTPM

Brain region

cerebral cortex: 15 nTPM
cerebellum: 14 nTPM
hippocampal formation: 13 nTPM
basal ganglia: 13 nTPM
amygdala: 13 nTPM
white matter: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.01
gnomAD missense Z: 1.27
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF48 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

APOBEC3C

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF48 as an antibody target. Whether an autoantibody or antibody against ZNF48 could matter depends on whether native ZNF48 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF48 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF48 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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