Seroatlas · Human Serome Atlas

DAPP1

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

Also known as: BAM32, DAPP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UN19
Gene: DAPP1
Ensembl: ENSG00000070190
Chromosome: 4
Canonical length: 280 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in protein dephosphorylation and signal transduction. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>Q9UN19|DAPP1
     1  MGRAELLEGK MSTQDPSDLW SRSDGEAELL QDLGWYHGNL TRHAAEALLL SNGCDGSYLL
    61  RDSNETTGLY SLSVRAKDSV KHFHVEYTGY SFKFGFNEFS SLKDFVKHFA NQPLIGSETG
   121  TLMVLKHPYP RKVEEPSIYE SVRVHTAMQT GRTEDDLVPT APSLGTKEGY LTKQGGLVKT
   181  WKTRWFTLHR NELKYFKDQM SPEPIRILDL TECSAVQFDY SQERVNCFCL VFPFRTFYLC
   241  AKTGVEADEW IKILRWKLSQ IRKQLNQGEG TIRSRSFIFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DAPP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

tonsil: 36 nTPM
lymph node: 32 nTPM
esophagus: 24 nTPM
appendix: 21 nTPM
spleen: 16 nTPM
bone marrow: 15 nTPM

Single-cell type

platelets: 816 nCPM
esophageal apical cells: 798 nCPM
urothelial cells: 714 nCPM
cdc: 285 nCPM
megakaryocytes: 253 nCPM
ocular epithelial cells: 253 nCPM

Immune cell

neutrophil: 138 nTPM
naive B-cell: 99 nTPM
memory B-cell: 91 nTPM
myeloid DC: 76 nTPM
eosinophil: 71 nTPM
classical monocyte: 70 nTPM

Brain region

white matter: 3.5 nTPM
medulla oblongata: 2.6 nTPM
pons: 2.4 nTPM
cerebral cortex: 2.2 nTPM
spinal cord: 2.2 nTPM
thalamus: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.17
gnomAD missense Z: 1.87
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DAPP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DAPP1 as an antibody target. Whether an autoantibody or antibody against DAPP1 could matter depends on whether native DAPP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DAPP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DAPP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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